Unique ID issued by UMIN | UMIN000033650 |
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Receipt number | R000038365 |
Scientific Title | Observational study on the effiacy of landiolol for the treatment of atrial tachyarrhythmias and predictor of outcome |
Date of disclosure of the study information | 2018/08/07 |
Last modified on | 2019/08/07 21:01:43 |
Observational study on the effiacy of landiolol for the treatment of atrial tachyarrhythmias and predictor of outcome
Landiolol in atrial tachyarrhythmias
Observational study on the effiacy of landiolol for the treatment of atrial tachyarrhythmias and predictor of outcome
Landiolol in atrial tachyarrhythmias
Japan |
atrial tachyarrhythmias
Cardiology |
Others
NO
To evaluate the theraputic effect of intravenous landiolol and outcome in patients with atrial tachyarrhythmias and heart failure.
Efficacy
Heart rate and blood pressure during intravenous infusion of landiolol
Restoration of sinus rhythm
Left ventricular ejection fraction
Plasma BNP
Total death
Hospitalization due to worsening heart failure
Observational
18 | years-old | <= |
90 | years-old | > |
Male and Female
Patients who underwent continuous intravenous infusion of raniorolol for the treatment of atrial tachyarrhythmias
Patients that are ineligible for this study (such as lack of information)
60
1st name | Nobuhisa |
Middle name | |
Last name | Hagiwara |
Tokyo Women's Medical University
Department of Cardiology
162-8666
8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
03-3353-8111
hagiwara.nobuhisa@twmu.ac.jp
1st name | Tsuyoshi |
Middle name | |
Last name | Shiga |
Tokyo Women's Medical University
Department of Cardiology
162-8666
8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
03-3353-8111
shiga.tsuyoshi@twmu.ac.jp
Tokyo Women's Medical University
Self-sourcing
Self funding
The Institutional Review Board of Tokyo Womens Medical University
8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
03-3353-8111
krinri.bm@twmu.ac.jp
NO
東京女子医科大学病院(東京都)
2018 | Year | 08 | Month | 07 | Day |
https://link.springer.com/content/pdf/10.1007%2Fs40801-019-0149-1.pdf
Published
https://link.springer.com/content/pdf/10.1007%2Fs40801-019-0149-1.pdf
67
The median maintenance dose of intravenous landiolol was 3.0 microg/kg/min. Intravenous landiolol reduced the heart rate without a marked reduction in blood pressure. During landiolol treatment, 15 (22%) patients had spontaneously restored sinus rhythm. Eight patients experienced in-hospital death, and 41(69%) were discharged with sinus rhythm. During the follow-up of 16 months, patients with sinus rhythm showed a lower frequency of rehospitalization due to HF than patients with ATAs (5/41 vs 7/18).
2019 | Year | 08 | Month | 07 | Day |
Total 67 consecutive patients with atrial tachyarrhythmias who were admitted to our hospital due to worsening heart failure from May 2014 to December 2017 at Tokyo Women's Medical University Hospital
All patients were included.
Landiolol treatment was discontinued in 3 patients because of the following adverse effects: hypotension(<90mmHg) in 2 patients and liver dysfunction in 1 patient.
The primary endpoints were changes in heart rate and systolic blood pressure from baseline during intravenous landiolol administration. The secondary endpoints included the restoration of sinus rhythm and outcomes.
Completed
2016 | Year | 09 | Month | 21 | Day |
2018 | Year | 02 | Month | 09 | Day |
2014 | Year | 05 | Month | 01 | Day |
2017 | Year | 12 | Month | 31 | Day |
2018 | Year | 09 | Month | 01 | Day |
2018 | Year | 10 | Month | 07 | Day |
2018 | Year | 10 | Month | 12 | Day |
Total 67 consecutive patients with atrial tachyarrhythmias who were admitted to our hospital due to worsening heart failure from May 2014 to December 2017 at Tokyo Women's Medical University Hospital were retrospectively included in this analysis.
2018 | Year | 08 | Month | 06 | Day |
2019 | Year | 08 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000038365
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