Unique ID issued by UMIN | UMIN000033978 |
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Receipt number | R000038749 |
Scientific Title | analysis of endoscopic brush samples identified mucosa associated dysbiosis and the expression of tight junction protein in functional dyspepsia. |
Date of disclosure of the study information | 2018/09/10 |
Last modified on | 2018/08/31 21:40:18 |
analysis of endoscopic brush samples identified mucosa associated dysbiosis and the expression of tight junction protein in functional dyspepsia.
mucosa associated dysbiosis and the expression of tight junction protein in functional dyspepsia.
analysis of endoscopic brush samples identified mucosa associated dysbiosis and the expression of tight junction protein in functional dyspepsia.
mucosa associated dysbiosis and the expression of tight junction protein in functional dyspepsia.
Japan |
Functional dyspepsia(FD)
Gastroenterology |
Others
NO
The aim of this present study was to clarify 1) the relationship between upper gastrointestinal symptoms in FD and the characteristics of the gastrointestinal MAM, from the oral cavity to the descending portion of duodenum by using 16S-rRNA V3-V4 gene sequences. 2) the targeting gut dysbiosis MAM to exacerbate symptoms in patients with FD by using some questionnaires.
Bio-equivalence
The characteristics of the gastrointestinal MAM in FD.
Observational
20 | years-old | <= |
75 | years-old | >= |
Male and Female
criteria of Rome4 in FD without infection of Hericobater pyroli
Additional exclusion criteria were as follows: administration of antibiotics, corticosteroids, immunosuppressants, and acid suppressing agents proton pump inhibitors (PPIs) and histamine-type 2 receptor blockers (H2 blockers) within the past 1 month, and a history of underlying malignant diseases.Patients with other factors that could affect intestinal motility or gut microbiota, as evaluated by researchers, were also ineligible.
40
1st name | |
Middle name | |
Last name | Yuji Naito |
Kyoto Prefectural University of Medicine
Department of Molecular Gastroenterology and Hepatology
465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
0752515519
ynaito@koto.kpu-m.ac.jp
1st name | |
Middle name | |
Last name | Akifumi Fukui |
North Medical Center Kyoto Prefectural University of Medicine
Department of Molecular Gastroenterology and Hepatology
481,Otokoyama, Yosano-cho, Yosano-gun, Kyoto 629-2261, Japan
0772463371
afukui@koto.kpu-m.ac.jp
Kyoto Prefectural University of Medicine
Japan Society for the Promotion of Science through a grant, Grants-in-Aid for Scientific Research (KAKENHI) (C) to Akifumi Fukui (No. 17K09358)
Japanese Governmental office
NO
2018 | Year | 09 | Month | 10 | Day |
Unpublished
Open public recruiting
2017 | Year | 05 | Month | 22 | Day |
2017 | Year | 05 | Month | 22 | Day |
Eleven FD patients and seven healthy volunteers subject without gastrointestinal mucosal inflammation or carcinoma or using antibiotics and acid suppressing agents within one month were enrolled.mucosa samples from the 2nd portion of duodenum were collected with a brush under endoscopic examination. MAM profiles of each sample were analyzed by 16S-rRNA V3-V4 gene sequences.
2018 | Year | 08 | Month | 31 | Day |
2018 | Year | 08 | Month | 31 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000038749
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