Unique ID issued by UMIN | UMIN000033992 |
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Receipt number | R000038761 |
Scientific Title | The effect of low dose tolvaptan after cardiovascular surgery |
Date of disclosure of the study information | 2018/09/03 |
Last modified on | 2021/03/05 10:10:55 |
The effect of low dose tolvaptan after cardiovascular surgery
The effect of low dose tolvaptan after cardiovascular surgery
The effect of low dose tolvaptan after cardiovascular surgery
The effect of low dose tolvaptan after cardiovascular surgery
Japan |
after cardiovascular surgery associated with cardiopulmonary bypass
Cardiovascular surgery |
Others
NO
early return to preoperative weight by using tolvaptan after open heart surgery
Safety,Efficacy
Whether returning to the target weight by the 6th postoperative day
worsening renal function, urine volume / body weight
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Azosemide 30 mg / day was administered from the 2nd postoperative day. Administer furosemide 10 to 40 mg as appropriate. Within 4 days to return to preoperative weight.
Azosemide 30 mg/day and tolvaptan 3.75 mg/day was administered from the 2nd postoperative day. Administer furosemide 10 to 40 mg as appropriate. Within 4 days to return to preoperative weight.
20 | years-old | <= |
Not applicable |
Male and Female
patients after open heart surgery with cardiopulmonary bypass
Urgency or emergency operation
CKD (dialysis, eGFR<30)
Heart failure with EF<40%
Heart failure or infection within preoperative 4 weeks
Thoracoabdominal aortic replacement surgery and OPCAB
Artificial respiration management over 24 hours and reintroduction
Tolvaptan allergy
Without feeling dry mouth or water ingestion
Hypernatremia
Patients with pregnant, possibility of pregnancy and pregnancy wish
Using tolvaptan preoperatively
240
1st name | Tadaaki |
Middle name | |
Last name | Koyama |
Kobe City Medical Center General Hospital
Cardiovascular Surgery
650-0047
2-1-1 Minatojimaminamimachi Chuouku Kobe City Hyogo Japan
078-302-4321
koyamat@kcho.jp
1st name | Tadaaki |
Middle name | |
Last name | Koyama |
Kobe City Medical Center General Hospital
Cardiovascular Surgery
650-0047
2-1-1 Minatojimaminamimachi Chuouku Kobe City Hyogo Japan
078-302-4321
koyamat@kcho.jp
Kobe City Medical Center General Hospital
none
Other
Kobe City Medical Center General Hospital
2-1-1 Minatojimaminamimachi Chuouku Kobe City Hyogo Japan
078-302-4321
rinken@kcho.jp
NO
2018 | Year | 09 | Month | 03 | Day |
Unpublished
Enrolling by invitation
2018 | Year | 08 | Month | 24 | Day |
2018 | Year | 08 | Month | 25 | Day |
2018 | Year | 09 | Month | 03 | Day |
2020 | Year | 12 | Month | 31 | Day |
2021 | Year | 01 | Month | 31 | Day |
2021 | Year | 02 | Month | 28 | Day |
2021 | Year | 03 | Month | 31 | Day |
2018 | Year | 09 | Month | 02 | Day |
2021 | Year | 03 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000038761
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