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UMIN-CTR Clinical Trial |
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Name: | UMIN ID: |
Recruitment status | Open public recruiting |
Unique ID issued by UMIN | UMIN000033998 |
Receipt No. | R000038770 |
Scientific Title | Significant Correlation between Renal 123I-Metaiodobenzylguanidine Scintigraphy and Muscle Sympathetic Nerve Activity in Patients with Heart Failure with Reduced Ejection Fraction |
Date of disclosure of the study information | 2018/09/03 |
Last modified on | 2020/03/05 |
Basic information | ||
Public title | Significant Correlation between Renal 123I-Metaiodobenzylguanidine Scintigraphy and Muscle Sympathetic Nerve Activity in Patients with Heart Failure with Reduced Ejection Fraction | |
Acronym | Study of renal MIBG in HFrEF patients | |
Scientific Title | Significant Correlation between Renal 123I-Metaiodobenzylguanidine Scintigraphy and Muscle Sympathetic Nerve Activity in Patients with Heart Failure with Reduced Ejection Fraction | |
Scientific Title:Acronym | Study of renal MIBG in HFrEF patients | |
Region |
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Condition | ||
Condition | HFrEF | |
Classification by specialty |
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Classification by malignancy | Others | |
Genomic information | NO |
Objectives | |
Narrative objectives1 | In this study, we hypothesized that HFrEF patients whose sympathetic nerves and humoral factor interaction are accelerated by pressure overloading, the dynamics of 123I is more likely to be observed. We compared renal MIBG and sympathetic nerve parameters and heart function indicators and examined how renal MIBG is related to cardiac function and circulatory dynamics. |
Basic objectives2 | Pharmacokinetics |
Basic objectives -Others | |
Trial characteristics_1 | Exploratory |
Trial characteristics_2 | Pragmatic |
Developmental phase | Not applicable |
Assessment | |
Primary outcomes | MIBG,MSNA |
Key secondary outcomes |
Base | |
Study type | Observational |
Study design | |
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Concealment |
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Gender | Male and Female | |||
Key inclusion criteria | HFrEF was defined according to the guidelines of the Japanese Circulation Society 10 for diagnosis and treatment of acute and chronic heart failure as left ventricular ejection fraction less than 40%. | |||
Key exclusion criteria | Patients with an estimated glomerular filtration rate of <50 ml/min/1.73 m2, morphological kidney abnormality, renal vascular stenosis, advanced lung disease, mental illness, or acute cardiovascular disease were excluded. | |||
Target sample size | 30 |
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Name of lead principal investigator |
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Organization | Kanazawa University | ||||||
Division name | cardiology | ||||||
Zip code | 920-0934 | ||||||
Address | Kanazawa city Takaramachi | ||||||
TEL | 09056828475 | ||||||
yosi3305@yahoo.co.jp |
Public contact | |||||||
Name of contact person |
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Organization | Kanazawa University | ||||||
Division name | cardiology | ||||||
Zip code | 920-0934 | ||||||
Address | Kanazawa city Takaramachi | ||||||
TEL | 0770223611 | ||||||
Homepage URL | |||||||
yosi3305@yahoo.co.jp |
Sponsor | |
Institute | Kanazawa University |
Institute | |
Department |
Funding Source | |
Organization | Kanazawa University |
Organization | |
Division | |
Category of Funding Organization | Japanese Governmental office |
Nationality of Funding Organization |
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Co-sponsor | |
Name of secondary funder(s) |
IRB Contact (For public release) | |
Organization | Kanazawa university hospital |
Address | Kanazawa city Takaramachi |
Tel | 09056828475 |
yosi3305@yahoo.co.jp |
Secondary IDs | |
Secondary IDs | NO |
Study ID_1 | |
Org. issuing International ID_1 | |
Study ID_2 | |
Org. issuing International ID_2 | |
IND to MHLW |
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Date of disclosure of the study information |
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Related information | |
URL releasing protocol | |
Publication of results | Unpublished |
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Progress | |||||||
Recruitment status | Open public recruiting | ||||||
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Other | |
Other related information | I have finished observing 20 cases |
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Link to view the page | |
URL(English) | https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000038770 |
Research Plan | |
Registered date | File name |
Research case data specifications | |
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Research case data | |
Registered date | File name |