Unique ID issued by UMIN | UMIN000034032 |
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Receipt number | R000038790 |
Scientific Title | A pathophysiological study in diabetes-related dementia |
Date of disclosure of the study information | 2018/10/01 |
Last modified on | 2020/03/10 11:25:13 |
A pathophysiological study in diabetes-related dementia
A pathophysiology in diabetes-related dementia
A pathophysiological study in diabetes-related dementia
A pathophysiology in diabetes-related dementia
Japan |
Dementia associated with dementia
Geriatrics |
Others
NO
Pathophysiological study
Others
Propose of clinical criteria
Amyloid and tau accumulation on PET
Amyloid and tau measurements in cerebrospinal fluid
Observational
60 | years-old | <= |
95 | years-old | >= |
Male and Female
Dementia associated with diabetes
Severe dementia
200
1st name | Haruo |
Middle name | |
Last name | Hanyu |
Tokyo Medical University
Geriatric Medicine
160-0023
6-7-1 Nishishinjuku Shinjuku-ku Tokyo 160-0023
03-3342-6111
h-hanyu@tokyo-med.ac.jp
1st name | Haruo |
Middle name | |
Last name | Hanyu |
Tokyo Medical University
Geriatric Medicine
160-0023
6-7-1 Nishishinjuku Shinjuku-ku Tokyo 160-0023
03-3342-6111
h-hanyu@tokyo-med.ac.jp
Tokyo Medical University
Department of Geriatric Medicine
Tokyo Medical University
Other
Tokyo Metropolitan Geriatric Hospital
Tokyo Medical University
6-7-1 Nishishinjuku Shinjuku-ku Tokyo
03-3342-6111
Adm-IRB@tokyo-med.ac.jp
NO
東京医科大学
2018 | Year | 10 | Month | 01 | Day |
Partially published
We studied amyloid (PiB) PET in 31 patients with cognitive impairment and dementia associated with type 2 diabetes mellitus, including 16 with Alzheimer disease (AD), 10 with mild cognitive impairment (MCI), and 5 with other types of dementia. Our PET study showed that 63% (10/16) of patients with AD, 40% (4/10) of patients with MCI, and 40% (2/5) of patients with other types of dementia showed amyloid positivity. Our results suggest that there are subgroups with neuronal damage independent of amyloid pathology among patients with clinically diagnosed AD associated with DM.
Enrolling by invitation
2018 | Year | 08 | Month | 01 | Day |
2017 | Year | 08 | Month | 29 | Day |
2018 | Year | 09 | Month | 01 | Day |
2020 | Year | 12 | Month | 31 | Day |
Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H. Classification of clinically diagnosed Alzheimer disease associated with diabetes based on amyloid and tau PET results. J Alzheimers Dis 2019;71:261-271.
2018 | Year | 09 | Month | 05 | Day |
2020 | Year | 03 | Month | 10 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000038790
Research Plan | |
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2020/03/10 | 研究計画書ver5.doc |
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