Unique ID issued by UMIN | UMIN000035055 |
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Receipt number | R000039311 |
Scientific Title | The effects of dietary high-protein yogurt on protein absorption in healthy adult men |
Date of disclosure of the study information | 2019/05/31 |
Last modified on | 2019/06/04 12:41:54 |
The effects of dietary high-protein yogurt on protein absorption in healthy adult men
The effects of dietary high-protein yogurt on protein absorption
The effects of dietary high-protein yogurt on protein absorption in healthy adult men
The effects of dietary high-protein yogurt on protein absorption
Japan |
Healthy adult males
Adult |
Others
NO
We randomly allocated twelve subjects to administer either the high-protein yogurt or the control unfermented dairy products to investigate the postprandial blood amino acid level, followed by a washout period. These subjects were then crossed over and received the alternative dairy products.
Efficacy
the blood amino acid areas under the curve (AUC) (total amino acids, essential amino acids, leucine, BCAA)
the maximum (Cmax) blood amino acid level (total amino acids, essential amino acids, leucine, BCAA)
Blood amino acid level at each blood collection time point (total amino acids, essential amino acids, leucine, BCAA)
the time to maximum concentration (Tmax) of amino acids (total amino acids, essential amino acids, leucine, BCAA)
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
Active
2
Prevention
Food |
Single dose administration of 100 g of the high protein yogurt in intervention period
Single dose administration of 200 mL of the control unfermented dairy product in control period
20 | years-old | <= |
30 | years-old | > |
Male
1) All subjects voluntarily signed the informed consent after detailed description and understanding of this study
2) 20-30 year old men
3) Subjects with BMI within normal range (18.5 kg/m2 =< BMI < 25.0 kg/m2)
1) Those who were administered ''drug'', such as H2 blocker, PPI, or digestive enzyme preparation, ''medicated products'', such as stomach medicine or digestive drugs, or ''supplement'' containing amino acids or protein, which may have effects on the protein absorption, within one month before the first administration of intervention or control food, or during this study.
2) Patients with diabetes mellitus
3) Patients with diseases or symptoms undergoing treatments
4) Those who may suffer from food allergy
5) Those who may suffer from lactose intolerance
6) Those who have smoking habits
7) Those who donated 200 mL or 400 mL of blood within one month or three months before giving written informed consent, respectively
8) Those who were included other clinical trials within one month before the first administration of intervention or control food, or during this study.
9) Any other medical and/or health reasons unfavorable to participation in this study, as judged by the principal investigator.
12
1st name | Shukuko |
Middle name | |
Last name | Ebihara |
Chiyoda para medical care clinic
Chiyoda para medical care clinic
101-0047
Chushin build 3-3-5 Uchikanda, Chiyodaku, Tokyo 101-0047, Japan
03-5297-5548
m.n@cpcc.co.jp
1st name | Takaya |
Middle name | |
Last name | Kitamura |
Meiji Co., Ltd.
R&D Total Oversight Department, R&D Division
192-0919
1-29-1 Nanakuni, Hachiouji, Tokyo 192-0919
042-632-5807
takaya.kitamura@meiji.com
Meiji Co., Ltd.
Meiji Co., Ltd.
Profit organization
Meiji Institutional Review Board
1-29-1 Nanakuni, Hachiouji, Tokyo 192-0919
042-632-5900
MEIJI.IRB@meiji.com
NO
チヨダパラメディカルケアクリニック
Chiyoda Paramedical Care Clinic
2019 | Year | 05 | Month | 31 | Day |
Published
12
1. The changes in AUC (delta AUC0-180) and Cmax (delta Cmax) of the blood essential amino acid concentrations after the consumption of the high-protein yogurt were higher than the control unfermented dairy products (p<0.1, and p<0.05, respectively).
2. The changes in AUC (delta AUC0-180) and Cmax (delta Cmax) of the blood branched-chain amino acid (BCAA) and leucine concentrations after the consumption of the high-protein yogurt were higher than the control unfermented dairy products (both p<0.05).
2019 | Year | 06 | Month | 04 | Day |
none
Completed
2018 | Year | 10 | Month | 12 | Day |
2018 | Year | 10 | Month | 11 | Day |
2018 | Year | 10 | Month | 20 | Day |
2018 | Year | 11 | Month | 03 | Day |
2018 | Year | 11 | Month | 28 | Day |
2019 | Year | 06 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039311
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