Unique ID issued by UMIN | UMIN000034615 |
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Receipt number | R000039465 |
Scientific Title | Examination of blood ghrelin and leptin concentrations during administration of calcimimetics |
Date of disclosure of the study information | 2018/10/24 |
Last modified on | 2020/07/08 16:27:29 |
Examination of blood ghrelin and leptin concentrations during administration of calcimimetics
Blood ghrelin and leptin levels during administration of calcimimetics
Examination of blood ghrelin and leptin concentrations during administration of calcimimetics
Blood ghrelin and leptin levels during administration of calcimimetics
Japan |
Chronic renal failure
Nephrology |
Others
NO
To evaluate the effect of calcimimetics on appetite in dialysis patients
Safety,Efficacy
Blood ghrelin and leptin concentration
Interview survey
Observational
20 | years-old | <= |
100 | years-old | >= |
Male and Female
Hemodialysis patients currently visiting our hospital
Patients complicated with serious diseases such as cancer, hematological disorders, and liver cirrhosis
10
1st name | Michio |
Middle name | |
Last name | Kuwahara |
Saitama Tsukinomori Clinic
Nephrology
339-0012
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
048-792-1811
kuwahara@k-naika-cl.jp
1st name | Michio |
Middle name | |
Last name | Kuwahara |
Saitama Tsukinomori Clinic
Nephrology
339-0012
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
048-792-1811
kuwahara@k-naika-cl.jp
Saitama Tsukinomori Clinic
Saitama Tsukinomori Clinic
Self funding
the ethics committee of Saitama Tsukinomori Clinic
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
0487921811
kuwahara@k-naika-cl.jp
NO
2018 | Year | 10 | Month | 24 | Day |
Unpublished
10
1. In 10 hemodialysis patients receiving cinacalcet, leptin was 0.67+0.09 (Log [leptin ng/mL]), active ghrelin was 1.22+0.13 (Log [active ghrelin fmol/mL]), and desacyl ghrelin was 2.15+0.18 (Log [desacyl ghrelin fmol/mL]).
2. In these patients, 8 weeks after changing from cinacalcet to evocalcet, leptin was 0.70+0.12 (Log [leptin ng/mL]) and active ghrelin was 1.37+0.11 (Log [active ghrelin fmol/mL]) , Desacyl ghrelin was 2.08+0.20 (Log [desacyl ghrelin fmol/mL]), and no significant change was observed
2020 | Year | 07 | Month | 08 | Day |
Terminated
2018 | Year | 10 | Month | 23 | Day |
2018 | Year | 10 | Month | 23 | Day |
2018 | Year | 10 | Month | 24 | Day |
2020 | Year | 03 | Month | 31 | Day |
The main results of this study are as follows.
1. Blood levels of leptin, activated ghrelin and desacyl ghrelin were measured in 70 dialysis patients in a pilot study. Although these values had a non-normal distribution, we found that they can be regarded as a normal distribution by logarithmic transformation. Therefore, statistical processing was performed using the logarithmic conversion value.
2. In 10 hemodialysis patients receiving cinacalcet, leptin was 0.67+0.09 (Log [leptin ng/mL]), active ghrelin was 1.22+0.13 (Log [active ghrelin fmol/mL]), and desacyl ghrelin was 2.15+0.18 (Log [desacyl ghrelin fmol/mL]).
3. In these patients, 8 weeks after changing from cinacalcet to evocalcet, leptin was 0.70+0.12 (Log [leptin ng/mL]) and active ghrelin was 1.37+0.11 (Log [active ghrelin fmol/mL]) , Desacyl ghrelin was 2.08+0.20 (Log [desacyl ghrelin fmol/mL]), and no significant change was observed.
Our hypothesis was that "after changing from cinacalcet to evocalcet, leptin decreases and active ghrelin increases," but the results did not match the hypothesis. Therefore, we conclude that further research is difficult.
2018 | Year | 10 | Month | 24 | Day |
2020 | Year | 07 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039465
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