Unique ID issued by UMIN | UMIN000034633 |
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Receipt number | R000039487 |
Scientific Title | Blood concentration of undercarboxylated osteocalcin (uc - OC) in hemodialysis patients using warfarin |
Date of disclosure of the study information | 2018/10/25 |
Last modified on | 2021/06/02 13:48:47 |
Blood concentration of undercarboxylated osteocalcin (uc - OC) in hemodialysis patients using warfarin
Blood undercarboxylated osteocalcin (uc - OC) in hemodialysis patients using warfarin
Blood concentration of undercarboxylated osteocalcin (uc - OC) in hemodialysis patients using warfarin
Blood undercarboxylated osteocalcin (uc - OC) in hemodialysis patients using warfarin
Japan |
Chronic renal failure
Nephrology |
Others
NO
To examine the effect of warfarin on bone metabolism of hemodialysis patients
Safety
Difference in blood concentration of uc - OC, bone alkaline phosphatase (BAP), tartarate - resistant acid phosphatase - 5 b (TRACP - 5 b) in hemodialysis patients taking warfarin and those not taking
Observational
20 | years-old | <= |
100 | years-old | > |
Male and Female
Hemodialysis patients in outpatient visit of Tsukinomori clinic, Kasukabe internal medicine clinic, or Koshigaya oobukuro clinic
Patients complicated with serious diseases such as cancer, hematological disorders, and liver cirrhosis
20
1st name | Satoshi |
Middle name | |
Last name | Kurihara |
Saitama Tsukinomori Clinic
Nephrology
339-0012
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
048-792-1811
kurihara@k-naika-cl.jp
1st name | Yasuyo |
Middle name | |
Last name | Matsukura |
Saitama Tsukinomori Clinic
Pharmaceutical division
339-0012
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
048-792-1811
matsukura@k-naika-cl.jp
Saitama Tsukinomori Clinic
Saitama Tsukinomori Clinic
Self funding
the ethics committee of Saitama Tsukinomori Clinic
366-1 Mashinaga, Iwatsuki-ku, Saitama city, Saitama 339-0012, Japan
0487921811
hayama@k-naika-cl.jp
NO
2018 | Year | 10 | Month | 25 | Day |
Saitama Dialysis Medical Society Journal 8: 61-65, 2019. There is no URL because it is not an ISSN.
Published
Saitama Dialysis Medical Society Journal 8: 61-65, 2019. There is no URL because it is not an ISSN.
30
The median OC of WF-HD was 106.1 ng / mL and the median uc-OC was 49.5 ng / mL, which were higher than the median OC of 14.2 ng / mL and the median uc-OC of 2.0 ng / mL in HS (P <0.001). The median OC / uc-OC ratio was 0.63 for WF-HD, which was higher than the median 0.22 for non WF-HD and 0.16 for HS (P <0.001). Vitamin K1 was lower in WF-HD and non WF-HD than in HS (P <0.001). Vitamin K2 was not significantly different in the three groups.
2021 | Year | 04 | Month | 29 | Day |
7 healthy subjects, 10 dialysis patients taking warfarin (WF), 13 dialysis patients not taking WF
There were 10 dialysis patients (WF-HD) taking warfarin at the three institutions that participated in the study. Thirteen dialysis patients who did not take WF (non-WF-HD) and seven healthy subjects (HS) that matched their age and gender were added.
No obvious adverse events were observed.
blood osteocalcin (OC) concentration, hypocarboxylated osteocalcin (uc-OC) concentration, vitamin K1 concentration, vitamin K2 concentration
Completed
2018 | Year | 10 | Month | 23 | Day |
2018 | Year | 10 | Month | 23 | Day |
2018 | Year | 10 | Month | 25 | Day |
2019 | Year | 10 | Month | 31 | Day |
2019 | Year | 11 | Month | 10 | Day |
2019 | Year | 11 | Month | 10 | Day |
2019 | Year | 11 | Month | 20 | Day |
This is a prospective observational study for hemodialysis patients. We are targeting patients in each hospital and we do not recruit general people.
2018 | Year | 10 | Month | 25 | Day |
2021 | Year | 06 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039487
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