Unique ID issued by UMIN | UMIN000034731 |
---|---|
Receipt number | R000039584 |
Scientific Title | Clinical evaluation of TEG6s PlateletMapping assay during cardiopulmonary bypass : A prospective observational study |
Date of disclosure of the study information | 2018/12/01 |
Last modified on | 2020/09/18 11:10:40 |
Clinical evaluation of TEG6s PlateletMapping assay during cardiopulmonary bypass : A prospective observational study
Clinical evaluation of TEG6s PlateletMapping assay during cardiopulmonary bypass.
Clinical evaluation of TEG6s PlateletMapping assay during cardiopulmonary bypass : A prospective observational study
Clinical evaluation of TEG6s PlateletMapping assay during cardiopulmonary bypass.
Japan |
1. Patients undergoing cardiovascular surgery using cardiopulmonary bypass
Anesthesiology | Cardiovascular surgery | Blood transfusion |
Intensive care medicine |
Others
NO
To evaluate whether Platelet Mapping ADP be able to indicate FFP transfusion during CPB
2) To evaluate whether Platelet Mapping ADP be able to indicate platelet transfusion after CPB
Efficacy
1. Correlation between plasma fibrinogen concentration and MAFibrin in Platelet Mapping assay.
2. Correlation between platelet count and MAADP, MAThrombin
1) Correlation between platelet inhibition (MAThrombin - MAADP) and medication history, duration of cardiopulmonary bypass
2) Comparing the data from the samples drawn at the end of the aortic cross clamping with those from the samples drawn after protamine administration
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patient undergoing an elective cardiovascular surgery using cardiopulmonary bypass in Tokyo Medical and Dental University
Patients who refuse obtainment of informed consent
40
1st name | |
Middle name | |
Last name | Tokujiro Uchida |
Tokyo Medical and Dental University Graduate School of Medicine
Department of Anesthesiology
1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan
03-5803-5325
pocanalysis-group@umin.ac.jp
1st name | |
Middle name | |
Last name | Yudai Yamamoto |
Tokyo Medical and Dental University Graduate School of Medicine
Department of Anesthesiology
1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan
03-5803-5325
pocanalysis-group@umin.ac.jp
Department of Anesthesiology, Tokyo Medical and Dental University, Graduate School of Medicine
Haemonetics Japan GK
Profit organization
Japan
NO
東京医科歯科大学医学部附属病院(東京都)
2018 | Year | 12 | Month | 01 | Day |
Unpublished
No longer recruiting
2018 | Year | 11 | Month | 30 | Day |
2019 | Year | 03 | Month | 19 | Day |
2019 | Year | 03 | Month | 19 | Day |
2020 | Year | 12 | Month | 31 | Day |
Data sampling: Clinical information listed below is recorded from patient's clinical record by POD2.Preoperative data: age, gender, height, body weight, diagnosis, planned operation, preoperative laboratory data (CBC, Chemistry, Coagulation, physiological exam), medication list Surgical data: duration of anesthesia, duration of surgery, duration of cardiopulmonary bypass, duration of aortic cross clamping, blood loss, urine output, transfusion, intraoperative arterial blood gas analysis.
Postoperative data: blood loss in the first 24hr, postoperative transfusion, laboratory data on POD1 and POD2, postoperative sternotomy for massive bleeding
2) Blood sampling and measurement
Blood (10mL) is sampled via arterial line at the time point listed below.
(1) Baseline: soon after the anesthetic induction
(2) During cardiopulmonary bypass: at the end of aortic cross clamping
(3) After the protamine administration
After the sampling, blood sample is divided into the tube for coagulation, CBC, and TEG6s platelet mapping and plasma sampling. Plasma samples are stored at -80 degree Celsius.
CBC, PT, APTT, and fibrinogen concentration are measured, and Platelet Mapping assay is performed.
2018 | Year | 11 | Month | 01 | Day |
2020 | Year | 09 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039584
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |