Unique ID issued by UMIN | UMIN000036904 |
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Receipt number | R000042057 |
Scientific Title | Correlation of delirium with oxidative stress of sepsis patients |
Date of disclosure of the study information | 2019/05/31 |
Last modified on | 2019/05/31 00:38:52 |
Correlation of delirium with oxidative stress of sepsis patients
Correlation of delirium with oxidative stress of sepsis patients
Correlation of delirium with oxidative stress of sepsis patients
Correlation of delirium with oxidative stress of sepsis patients
Japan | Asia(except Japan) | North America |
South America | Australia | Europe |
Africa |
sepsis
Emergency medicine | Intensive care medicine |
Others
NO
To examine the association between oxidative stress of sepsis patients and delirium
Efficacy
Plasma vitamin C concentration and delirium
Oxidative stress marker,inflammatory marker and biochemical exam
Observational
Not applicable |
Not applicable |
Male and Female
sepsis patients
none
20
1st name | Yoshihide |
Middle name | |
Last name | Kuribayashi |
Tsurumi Hospital
Department of Anesthesiology
874-8585
4333 Tsurumi, Beppu City, Oita
0977-23-7111
kuribayashi@oita-u-ac.jp
1st name | Yoshihide |
Middle name | |
Last name | Kuribayashi |
Tsurumi Hospital
Department of Anesthesiology
874-8585
4333 Tsurumi, Beppu City, Oita
0977-23-7111
kuribayashi@oita-u-ac.jp
Tsurumi Hospital
Oita University, Faculty of Medicine, Department of Anesthesiology
Self funding
Tsurumi Hospital
4333 Tsurumi, Beppu City, Oita
0977-23-7111
kuribayashi@oita-u-ac.jp
NO
2019 | Year | 05 | Month | 31 | Day |
Unpublished
Enrolling by invitation
2018 | Year | 04 | Month | 01 | Day |
2018 | Year | 05 | Month | 01 | Day |
2018 | Year | 06 | Month | 01 | Day |
2019 | Year | 05 | Month | 31 | Day |
Postoperative delirium (POD) affects approximately 20 - 30 % of patients after cardiovascular surgery and is associated with increased mortality and persistent cognitive decline, and the prevention of POD is a matter of the highest urgency. Patients undergoing cardiac surgery increase the production of reactive oxygen species and induce oxidative injury due to tissue hypoxia, ischemia and hyperoxic reperfusion. Therefore, intraoperative oxidative injury may contribute to postoperative brain injury and subsequent POD. We conducted this study to test the hypothesis that perioperative oxidative stress is associated with the department of POD following cardiac surgery. If the hypothesis holds true, we hope future studies to determine whether interventions that reduce oxidative stress decrease POD.
2019 | Year | 05 | Month | 31 | Day |
2019 | Year | 05 | Month | 31 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042057
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