Unique ID issued by UMIN | UMIN000037103 |
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Receipt number | R000042281 |
Scientific Title | Use of Pregabalin for attenuation of hemodymanic response to laryngoscopy and intubation in treated hypertensive patients |
Date of disclosure of the study information | 2019/06/19 |
Last modified on | 2020/07/03 00:43:24 |
Use of Pregabalin for attenuation of hemodymanic response to laryngoscopy and intubation in treated hypertensive patients
Use of Pregabalin for attenuation of hemodymanic response to laryngoscopy and intubation in treated hypertensive patients
Use of Pregabalin for attenuation of hemodymanic response to laryngoscopy and intubation in treated hypertensive patients
Use of Pregabalin for attenuation of hemodymanic response to laryngoscopy and intubation in treated hypertensive patients
Asia(except Japan) |
premptive pregabalin in hypertensive patient
Anesthesiology |
Others
NO
To look the response of preemptive Pregabalin in attenuating the hemodynamic response to laryngoscopy and intubation in treated hypertensive patients.
Efficacy
Response of preemptive Pregabalin in attenuating the hemodynamic response to laryngoscopy and intubation in treated hypertensive patients.
1. pre-operative anxiety level
2. heart rate
3. systolic and diastolic pressure.
4. mean arterial pressure.
5. side effects
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Placebo
NO
NO
2
Prevention
Medicine |
A thorough pre-anaesthetic assessment and investigations will be performed before patient selection. An informed written consent will be taken in all the patients. All the patients will be pre-medicated with tab Dizepam 5 mg a night before surgery. All 50 enrolled patients will be randomized to one of the two oral premedication treatment groups of 25 patients each.Group II will recieve Cap. Pregabalin (75 mg), given with sips of water 60 minutes before induction of general anesthesia.
Group I will receive placebo (Vitamin b/c)
30 | years-old | <= |
70 | years-old | >= |
Male and Female
1. Scheduled for elective surgery under general anesthesia .
2. All patients with controlled hypertension.
3. All patients of ASA physical status II.
4. Patient aged 30-70 years.
1. Unwilling patients.
2. Patients with ASA grade III or higher.
3. Pre-existing cardiac disease, asthma, and severe renal or hepatic dysfunction.
4. Anticipated difficult intubation.
5. Patients with morbid obesity.
6. History of taking antidepressants drugs.
50
1st name | Puja |
Middle name | |
Last name | Thapa |
Nepalese Army Institute Of Health Sciences
Bagmati
44600
Chhauni,Kathmandu
+9779851152449
thapa_puza@yahoo.com
1st name | Puja |
Middle name | |
Last name | Thapa |
Nepalese Army Institute of Health Sciences
Bagmati
44600
Chhauni, Kathmandu
009779851152449
http://naihs.edu.np/
thapa_puza@yahoo.com
Nepalese Army Institute of Health Sciences.
Nepalese Army Institute of Health Sciences
Self funding
Nepalese Army Institute of Health Sciences
Sanobharyang, kathmandu
+977-1-4881259
info@naihs.edu.np
NO
2019 | Year | 06 | Month | 19 | Day |
NA
Published
https://www.nepjol.info/index.php/nmj/article/view/25715
50
A total of 50 patients, 25 in each arm were enrolled. The baseline characteristics were comparable. SBP was significantly lower in the Pregabalin group than in Placebo at all the periods of recording, however, DBP and MAP decreased significantly during, after 1 and 3 minutes of laryngoscopy (p=0.001). Sedation was significantly better in the Pregabalin group with 86% in RSS 3 compared to 80% of a placebo arm in RSS2 (P <0.001).
2020 | Year | 07 | Month | 03 | Day |
Both arms have similar baseline characteristics and they do not differ .
Randomized into two groups
None observed
Intraoperatively, the heart rate,
MAP, electrocardiography, pulse oximeter (SpO2) and EtCO2
levels were continuously monitored and recorded before and
during induction, during laryngoscopy and 1, 3 and 5 min after
intubation.
Completed
2018 | Year | 01 | Month | 15 | Day |
2018 | Year | 03 | Month | 01 | Day |
2018 | Year | 03 | Month | 05 | Day |
2018 | Year | 06 | Month | 30 | Day |
2019 | Year | 06 | Month | 19 | Day |
2020 | Year | 07 | Month | 03 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042281
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