Unique ID issued by UMIN | UMIN000037133 |
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Receipt number | R000042320 |
Scientific Title | Detecting low allele frequency of compound minor mutation using high-sensitivity next generation sequencer for EGFR mutant lung cancer |
Date of disclosure of the study information | 2019/06/21 |
Last modified on | 2019/06/21 21:19:32 |
Detecting low allele frequency of compound minor mutation using high-sensitivity next generation sequencer for EGFR mutant lung cancer
Detecting compound minor mutation using NGS for EGFR mutant lung cancer
Detecting low allele frequency of compound minor mutation using high-sensitivity next generation sequencer for EGFR mutant lung cancer
Detecting compound minor mutation using NGS for EGFR mutant lung cancer
Japan |
EGFR-mutant lung cancer
Pneumology | Hematology and clinical oncology |
Malignancy
YES
The aim of this study is to prospectively investigate detecting rate of EGFR compound minor mutation containing Ex20 T790M using high-sensitivity NGS at diagnostic phase and re-biopsy phase to compare the subsequence genetic change.
Efficacy
Exploratory
Detection rate of EGFR compound minor mutation using NGS
1) Allele frequency of sensitive mutation and compound minor mutation, and its corelation for response rate and PFS.
2) T790M detection rate at diagnostic phase and re-biopsy phase
3) Subsequent allele frequency change of EGFR compound minor mutation
Observational
20 | years-old | <= |
Not applicable |
Male and Female
1) EGFR-mutant lung cancer
2) Written informed consent
Other cases attending physician it is determined unsuitable for registration of the study
20
1st name | Kei |
Middle name | |
Last name | Morikawa |
St. Marianna University School of Medicine
Division of Respiratory Diseases, Department of Internal Medicine
216-8511
2-16-1 Sugao Miyamae-ku, Kawasaki
044-977-8111
mokke5454@yahoo.co.jp
1st name | Kei |
Middle name | |
Last name | Morikawa |
St. Marianna University School of Medicine
Division of Respiratory Diseases, Department of Internal Medicine
216-8511
2-16-1 Sugao Miyamae-ku, Kawasaki
044-977-8111
mokke5454@yahoo.co.jp
St. Marianna University School of Medicine
Boehringer Ingelheim GmbH
Profit organization
St. Marianna University School of Medicine
2-16-1 Sugao Miyamae-ku, Kawasaki
044-977-8111
mokke5454@yahoo.co.jp
YES
#4395
St. Marianna University School of Medicine
聖マリアンナ医科大学
2019 | Year | 06 | Month | 21 | Day |
Unpublished
Enrolling by invitation
2019 | Year | 05 | Month | 01 | Day |
2019 | Year | 06 | Month | 13 | Day |
2019 | Year | 06 | Month | 21 | Day |
2022 | Year | 03 | Month | 31 | Day |
ongoing
2019 | Year | 06 | Month | 21 | Day |
2019 | Year | 06 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042320
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