Unique ID issued by UMIN | UMIN000037213 |
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Receipt number | R000042429 |
Scientific Title | Clinical application of novel serum peptide biomarkers for dementia with Lewy bodies |
Date of disclosure of the study information | 2019/07/01 |
Last modified on | 2023/08/19 17:01:35 |
Clinical application of novel blood biomarkers for dementia with Lewy bodies
Application of blood biomarkers for dementia with Lewy bodies
Clinical application of novel serum peptide biomarkers for dementia with Lewy bodies
Application of serum peptide biomarkers for dementia with Lewy bodies
Japan |
Dementia with Lewy bodies, Alzheimer's diseases, Other senile dementia, Other senile psychosis, Parkinson's disease, Parkinson's syndrome, Mild cognitive impairment, Healthy condition
Psychiatry |
Others
NO
To evaluate the usefulness of serum peptide biomarker candidates for dementia with Lewy bodies
Others
To analyze the association of the above peptides with the pathophysiology of dementia with Lewy bodies
Confirmatory
Explanatory
Not applicable
To evaluate whether the biomarker models of serum peptide ion intensity distinguish dementia with Lewy bodies from other diseases and healthy condition
To evaluate the effect of the above peptides on neural cells
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients diagnosed with the above target diseases in St. Marianna University Hospital. Healthy individuals who had a medical check in St. Marianna University Hospital. Healthy individuals who are staffs in St. Marianna University and St. Marianna University Hospital.
Patients with moderate or severe anemia.
600
1st name | Manae |
Middle name | Suzuki |
Last name | Kurokawa |
St. Marianna University Graduate School of Medicine
Disease Biomarker Analysis and Molecular Regulation
216-8511
2-16-1, Sugao, Miyamae-ku, Kawasaki
81-44-977-8111
manae@marianna-u.ac.jp
1st name | Manae |
Middle name | Suzuki |
Last name | Kurokawa |
St. Marianna University Graduate School of Medicine
Disease Biomarker Analysis and Molecular Regulation
216-8511
2-16-1, Sugao, Miyamae-ku, Kawasaki
81-44-977-8111
manae@marianna-u.ac.jp
St. Marianna University School of Medicine
St. Marianna University School of Medicine
Self funding
Division of Graduate Student Affairs and Research Promotion
2-16-1, Sugao, Miyamae-ku, Kawasaki
81-44-977-8111
k-sienbu.mail@marianna-u.ac.jp
NO
2019 | Year | 07 | Month | 01 | Day |
Published
182
As a biomarker for dementia with Lewy bodies (DLB), DLB/nonDLB-4P (4 serum peptide) model provided sensitivity of 90.0% and specificity of 88.6%. DLB/nonDLB-2P model provided sensitivity of 95.0% and specificity of 93.3% for discriminating DLB from Alzheimer's disease. The parent proteins were involved in the pathology of DLB or Parkinson's disease and hippocampal neurogenesis. Serum peptides provided useful DLB biomarker candidates and may be implicated in the pathophysiology of the disease.
2023 | Year | 08 | Month | 19 | Day |
Completed
2018 | Year | 01 | Month | 10 | Day |
2018 | Year | 02 | Month | 09 | Day |
2018 | Year | 02 | Month | 10 | Day |
2023 | Year | 03 | Month | 31 | Day |
We evaluate the usefulness of DLB/nonDLB-4P and -2P models (Int J Geriatr Psychiatry 2015;30:1195) by mass spectrometry and ELISA.
2019 | Year | 06 | Month | 30 | Day |
2023 | Year | 08 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042429
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