Unique ID issued by UMIN | UMIN000037363 |
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Receipt number | R000042600 |
Scientific Title | The Effects of Benzodiazepine and Orexin Receptor Antagonist on Cognitive Function Revealed by Auditory Event-related Potentials |
Date of disclosure of the study information | 2019/07/15 |
Last modified on | 2019/07/13 15:49:01 |
The Effects of Benzodiazepine and Orexin Receptor Antagonist on Cognitive Function Revealed by Auditory Event-related Potentials
ERPs reflect BZ and suvorexant effects on cognition
The Effects of Benzodiazepine and Orexin Receptor Antagonist on Cognitive Function Revealed by Auditory Event-related Potentials
ERPs reflect BZ and suvorexant effects on cognition
Japan |
Insomnia
Psychiatry | Adult |
Others
NO
The purpose of this study is to estimate the cognitive decline 1 day after oral medication with lormetazepam, a benzodiazepine, and suvorexant, an orexin receptor antagonist, by comparing mismatch negativity (MMN) and P300 reflecting auditory discrimination function.
Pharmacodynamics
Individual mean amplitudes of mismatch negativity (MMN) and P300 1 day after oral administration of lormetazapam and suvorexant.
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
3
Treatment
Medicine |
Receiving suvorexant 20 mg
Receiving lormetazepam 2 mg
Receiving placebo
20 | years-old | <= |
Not applicable |
Male and Female
Healthy participants aged 20 years and older
History of mental illness and neurological disorder
60
1st name | Tetsuyta |
Middle name | |
Last name | Shiga |
Fukushima Medical University
Department of Neuropsychiatry
960-1295
Hikarigaoka 1, Fukushima
024-547-1331
tetsuya3@fmu.ac.jp
1st name | Tetsuya |
Middle name | |
Last name | Shiga |
Fukushima Medical University
Department of Neuropsychiatry
960-1295
Hikarigaoka 1, Fukushima
024-547-1331
tetsuya3@fmu.ac.jp
Fukushima Medical University
Fukushima Medical University
Other
Ethics Committee of Fukushima Medical University
Hikarigaoka 1, Fukushima
024-547-1111
rs@fmu.ac.jp
NO
2019 | Year | 07 | Month | 15 | Day |
Unpublished
60
Completed
2016 | Year | 01 | Month | 01 | Day |
2016 | Year | 01 | Month | 19 | Day |
2016 | Year | 02 | Month | 01 | Day |
2019 | Year | 01 | Month | 31 | Day |
2019 | Year | 07 | Month | 13 | Day |
2019 | Year | 07 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042600
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