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UMIN-CTR Clinical Trial |
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Name: | UMIN ID: |
Recruitment status | Main results already published |
Unique ID issued by UMIN | UMIN000037502 |
Receipt No. | R000042747 |
Scientific Title | Clinicopahological characteristics of retroperitoneal liposarcoma: Benefit of surgery for recurrence |
Date of disclosure of the study information | 2019/07/26 |
Last modified on | 2020/08/04 |
Basic information | ||
Public title | Characteristics of retroperitoneal liposarcoma: Surgery for recurrence | |
Acronym | Characteristics of retroperitoneal liposarcoma | |
Scientific Title | Clinicopahological characteristics of retroperitoneal liposarcoma: Benefit of surgery for recurrence | |
Scientific Title:Acronym | Clinicopahological characteristics of retroperitoneal liposarcoma | |
Region |
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Condition | ||
Condition | Retroperitoneal liposarcoma | |
Classification by specialty |
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Classification by malignancy | Malignancy | |
Genomic information | NO |
Objectives | |
Narrative objectives1 | To describe clinicopathological characteristics of primary and recurrent retroperitoneal liposarcoma. |
Basic objectives2 | Others |
Basic objectives -Others | descriptive and exploratory study |
Trial characteristics_1 | Exploratory |
Trial characteristics_2 | Explanatory |
Developmental phase | Not applicable |
Assessment | |
Primary outcomes | Overall survival
Recurrence free survival |
Key secondary outcomes |
Base | |
Study type | Observational |
Study design | |
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Randomization | |
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Stratification | |
Dynamic allocation | |
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Blocking | |
Concealment |
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Eligibility | ||||
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Gender | Male and Female | |||
Key inclusion criteria | Patients who admitted to Nagoya University hospital between January 2005 and December 2018 and were diagnosed as having reteroperitoneal liposarcoma | |||
Key exclusion criteria | Patients whose age was less than 20 years when this study strated | |||
Target sample size | 50 |
Research contact person | |||||||
Name of lead principal investigator |
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Organization | Nagoya University Graduate School of Medicine | ||||||
Division name | Perioperative medicine | ||||||
Zip code | 466-8560 | ||||||
Address | 65 Tsurumai-cho Showa-ku Nagoya Aichi | ||||||
TEL | 052-744-2222 | ||||||
yyoko@med.nagoya-u.ac.jp |
Public contact | |||||||
Name of contact person |
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Organization | Nagoya University Graduate School of Medicine | ||||||
Division name | Surgical Oncology | ||||||
Zip code | 466-8560 | ||||||
Address | 65 Tsurumai-cho Showa-ku Nagoya Aichi | ||||||
TEL | 052-744-2222 | ||||||
Homepage URL | |||||||
kenta-i@med.nagoya-u.ac.jp |
Sponsor | |
Institute | Nagoya University Graduate School of Medicine |
Institute | |
Department |
Funding Source | |
Organization | Self funding |
Organization | |
Division | |
Category of Funding Organization | Self funding |
Nationality of Funding Organization |
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Name of secondary funder(s) |
IRB Contact (For public release) | |
Organization | Ethics Committee of Nagoya University Graduate School of Medicine |
Address | 65 Tsurumai-cho Showa-ku Nagoya Aichi |
Tel | 052-744-2061 |
ethics@med.nagoya-u.ac.jp |
Secondary IDs | |
Secondary IDs | NO |
Study ID_1 | |
Org. issuing International ID_1 | |
Study ID_2 | |
Org. issuing International ID_2 | |
IND to MHLW |
Institutions | |
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Other administrative information | |||||||
Date of disclosure of the study information |
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Related information | |
URL releasing protocol | https://academic.oup.com/jjco/article/doi/10.1093/jjco/hyaa126/5874834 |
Publication of results | Published |
Result | |||||||
URL related to results and publications | https://academic.oup.com/jjco/article/doi/10.1093/jjco/hyaa126/5874834 | ||||||
Number of participants that the trial has enrolled | 52 | ||||||
Results | The patients undergoing R0 resection had significantly higher recurrence-free survival rates than the patients undergoing non-R0 resection.(p=0.033) The recurrence rates were 65, 67, 73 and 100% after the first, second, third and fourth surgeries. The 5-year overall survival rates were 82, 69, 40 and 0% after the first, second, third and fourth surgeries. | ||||||
Results date posted |
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Baseline Characteristics | Fifty-two patients with retroperitoneal liposarcoma were analysed. Among them, 46 patients had undergone surgery. Histologic grades included well-differentiated (n=21), dedifferentiated (n=21), myxoid (n=3) and pleomorphic (n=1). The median age was 61 years, and 29 patients (56%) were male. | ||||||
Participant flow | Fifty-two patients with primary retroperitoneal liposarcoma were analysed. Amongst them, 46 patients (88%) had undergone surgery. | ||||||
Adverse events | None | ||||||
Outcome measures | 3-year recurrence-free survival, 5-year recurrence-free survival, 5-year overall survival, 10-year overall survival | ||||||
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IPD sharing Plan description |
Progress | |||||||
Recruitment status | Main results already published | ||||||
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Other related information | A total of 52 patients with retroperitoneal liposarcoma were analyzed. The associations between clinicopathological factors and OS/RFS were investigated. |
Management information | |||||||
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Link to view the page | |
URL(English) | https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042747 |
Research Plan | |
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Research case data | |
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