Unique ID issued by UMIN | UMIN000038034 |
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Receipt number | R000043358 |
Scientific Title | A study of new exercise effects using anti-oxidative phenomenon by mitohormesis. |
Date of disclosure of the study information | 2019/09/18 |
Last modified on | 2023/04/09 03:21:40 |
A study of new exercise effects using anti-oxidative phenomenon by mitohormesis.
A study of new exercise effects using anti-oxidative phenomenon by mitohormesis.
A study of new exercise effects using anti-oxidative phenomenon by mitohormesis.
A study of new exercise effects using anti-oxidative phenomenon by mitohormesis.
Japan |
Healthy subjects
Adult |
Others
NO
The purpose of this study is to demonstrate whether mitohormesis is observed or not by light exercise training to keep health.
Efficacy
The changes of mRNA related mitohormesis by exercise(mRNA expressions of antioxidant-related gene(PGC-1a,SOD,catalase,GPx,NOX,XOR,arginase etc)and sulfide metabolizing enzyme-related(SQR,CARS2))
The association of individual life styles with marker related mitohormesis and Oxidative stress marker in blood (TBARS,NOx(NO2 and NO3),arginase etc).
Interventional
Cross-over
Non-randomized
Open -no one is blinded
No treatment
2
Prevention
Behavior,custom |
[Group A:Total 14 people
(7people who have no exercise habits.
7people who have exercise habits.)]
Intervention(2weeks:5days/week)30min Jogging(about 5km)
-Cooling(2weeks)
-Non intervention(2weeks)
This study needs 6weeks.
[Group B:Total 14 people
(7people who have no exercise habits.
7people who have exercise habits.)]
Non intervention(2weeks)
-Cooling(2weeks)
-Intervention(2weeks:5days/week)30min Jogging(about 5km)
This study needs 6weeks.
20 | years-old | <= |
Not applicable |
Male and Female
People who have no exercise habits and exercise habits.
Subjects who sign an informed consent form to participate in this study .
People who don't agree.
People who are currently undergoing treatment.
28
1st name | Keiki |
Middle name | |
Last name | Ogino |
Kochi Medical School
Department of Environmental Medicine
783-8505
Kohasu,Oko-cho,Nankoku-city,Kochi,Japan
0888882919
kogino@kochi-u.ac.jp
1st name | Keiki |
Middle name | |
Last name | Ogino |
Kochi Medical School
Department of Environmental Medicine
783-8505
Kohasu,Oko-cho,Nankoku-city,Kochi,Japan
0888882919
kogino@kochi-u.ac.jp
Kochi Medical School
Department of Environmental Medicine
Japan Society for the Promotion of Science
Other
Kochi Medical School, Center for Next Generation Medicine
Kohasu,Oko-cho,Nankoku-city,Kochi,Japan
0888802719
im62@kochi-u.ac.jp
NO
高知大学(高知県)
2019 | Year | 09 | Month | 18 | Day |
https://krinri.cc.kochi-u.ac.jp/plan_ethical/app_form.php?id=ERB-108444
Published
https://www.jstage.jst.go.jp/article/jcbn/69/2/69_21-24/_article
14
Primary endpoint: SOD1 and SOD2 mRNA levels were significantly increased after exercise intervention compared to pre-exercise. Secondary endpoints: the oxidative stress marker MDA decreased slightly immediately after exercise and increased significantly after 2 weeks of exercise; the increase in SOD2 was independent of prior exercise habits, but at baseline, SOD2 was significantly higher in those with exercise habits than those without.
2023 | Year | 04 | Month | 09 | Day |
Average age 23.4, male/female 11/3, no smoking habit, 7 with exercise habit
Participants were recruited for the Kochi University Environmental Medicine Practicum and 14 entered the program. Initially, a crossover study was planned, but due to departmental program constraints, only Intervention 1 was to be conducted instead of Intervention 2.
N/A
Changes in mitohormesis-related markers by exercise intervention and their association with activity habits.
Antioxidant enzyme-related genes (PGC1a, SOD, catalase, GPx, NOX, XOR, arginase, etc.),
Oxidative stress markers in blood (TBARS, NOx (NO2 and NO3), arginase, etc.)
Main results already published
2019 | Year | 11 | Month | 07 | Day |
2019 | Year | 10 | Month | 30 | Day |
2019 | Year | 11 | Month | 07 | Day |
2021 | Year | 03 | Month | 31 | Day |
2025 | Year | 03 | Month | 31 | Day |
2025 | Year | 03 | Month | 31 | Day |
2025 | Year | 03 | Month | 31 | Day |
2019 | Year | 09 | Month | 18 | Day |
2023 | Year | 04 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000043358
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