Unique ID issued by UMIN | UMIN000039887 |
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Receipt number | R000045485 |
Scientific Title | Evaluation of the efficacy of molecular targeted drugs using biopsy samples in patients with advanced hepatocellular carcinoma |
Date of disclosure of the study information | 2020/03/20 |
Last modified on | 2024/02/16 12:33:37 |
Evaluation of the efficacy of molecular targeted drugs using biopsy samples in patients with advanced hepatocellular carcinoma
Evaluation of the efficacy of targeted drugs using biopsy samples from HCC
Evaluation of the efficacy of molecular targeted drugs using biopsy samples in patients with advanced hepatocellular carcinoma
Evaluation of the efficacy of molecular targeted drugs using biopsy samples in patients with advanced hepatocellular carcinoma
Japan |
hepatocellular carcinoma
Hepato-biliary-pancreatic medicine |
Malignancy
NO
To assess the relationship between the histological change in HCC obtained at Week 4 and the subsequent survival outcomes
Efficacy
Histological treatment effects obtained four weeks after the start of molecular targeted drugs
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Maneuver |
liver tumor biopsy
20 | years-old | <= |
Not applicable |
Male and Female
Patients with advanced HCC in whom the first-line molecular targeted therapy or combined molecular targeted plus immune checkpoint inhibitor therapy begins within four weeks
Patients with allergy to lenvatinib, sorafenib, bevacizumab, atezolizumab, local anesthetics, or analgesics
Patients with severe ascites, severe renal failure, severe anemia, severe thrombocytopenia, jaundice, or coagulation disorder
Patients who need to take anticoagulants or anti-platelet drugs continuously
Patients with severe cognitive dysfunction or psychiatric disorders
Patients with severe heart failure
Pregnant or nursing mothers, woman who desire to bear children
50
1st name | Shiro |
Middle name | |
Last name | Oka |
Hiroshima University Hospital
Department of Gastroenterology
734-8551
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
082-257-5190
oka4683@hiroshima-u.ac.jp
1st name | Tomokazu |
Middle name | |
Last name | Kawaoka |
Hiroshima University Hospital
Department of Gastroenterology
734-8551
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
082-257-5193
kawaokatomo@hiroshima-u.ac.jp
Department of Gastroenterology and Metabolism, Hiroshima University Hospital
Department of Gastroenterology, Hiroshima University Hospital
Self funding
Independent Ethics Committee, Hiroshima University Hospital
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
082-257-1576
iryo-seisaku@office.hiroshima-u.ac.jp
NO
2020 | Year | 03 | Month | 20 | Day |
Unpublished
Enrolling by invitation
2020 | Year | 03 | Month | 19 | Day |
2020 | Year | 03 | Month | 19 | Day |
2020 | Year | 04 | Month | 01 | Day |
2027 | Year | 12 | Month | 31 | Day |
2020 | Year | 03 | Month | 20 | Day |
2024 | Year | 02 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045485
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