Unique ID issued by UMIN | UMIN000039950 |
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Receipt number | R000045553 |
Scientific Title | PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection |
Date of disclosure of the study information | 2020/03/26 |
Last modified on | 2020/03/26 12:33:32 |
PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection
PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection
PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection
PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection
Japan |
hepatocellular carcinoma
Hepato-biliary-pancreatic surgery |
Malignancy
YES
SNP in the promoter region of PD-1 -606 G / A has been reported to result in high activation and expression of PD-1 associated with cancer risk.
Others
Influence of PD-1 gene on recurrence in patients with HCC
The primary end point is overall survival.
Observational
31 | years-old | <= |
91 | years-old | >= |
Male and Female
The inclusion criteria were as follows: the tumor was histologically diagnosed as HCC; no distant metastasis was detected in the preoperative image; hepatectomy for HCC was conducted for the first time; and absence of any other malignancies.
Exclusion for above statement.
321
1st name | Masateru |
Middle name | |
Last name | Yamamoto |
Hiroshima University
Department of Gastroenterological and Transplant Surgery
734-8551
1-2-3 Kasumi, Kasumi Minami-ku, Hiroshima
082-257-5555
mayamamoto@hiroshima-u.ac.jp
1st name | Masateru |
Middle name | |
Last name | Masateru |
Hiroshima University
Department of Gastroenterological and Transplant Surgery
734-8551
1-2-3 Kasumi, Kasumi Minami-ku, Hiroshima
082-257-5555
mayamamoto@hiroshima-u.ac.jp
Hiroshima University
Hiroshima University
Self funding
Hiroshima University
1-2-3 Kasumi, Kasumi Minami-ku, Hiroshima
082-257-5555
mayamamoto@hiroshima-u.ac.jp
NO
2020 | Year | 03 | Month | 26 | Day |
Unpublished
321
Completed
2018 | Year | 04 | Month | 01 | Day |
2018 | Year | 06 | Month | 01 | Day |
2018 | Year | 07 | Month | 01 | Day |
2019 | Year | 04 | Month | 01 | Day |
The PD-1 SNP is associated with poor survival and increased EHR in HCC. Furthermore, that is an independent predictive factor for OS and EHR.
2020 | Year | 03 | Month | 26 | Day |
2020 | Year | 03 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045553
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