Unique ID issued by UMIN | UMIN000040317 |
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Receipt number | R000046001 |
Scientific Title | Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators |
Date of disclosure of the study information | 2020/05/07 |
Last modified on | 2023/11/09 09:14:43 |
Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators
Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators
Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators
Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators
Japan |
esophageal achalasia and achalasia-related diseases
Gastroenterology | Gastrointestinal surgery |
Others
NO
Patients undergoing POEM treatment for esophageal achalasia and achalasia-related diseases will be targeted, and patients with non-esophageal motor dysfunction such as esophageal cancer who will undergo esophagectomy will serve as a control group. Involvement of achalasia and virus infection, especially microRNA expression analysis of herpesvirus (HSV-1, HSV-2 etc.) and analysis of its regulatory molecule by collecting esophageal muscle layer sample of LES part and performing transcriptome analysis. I do.
Others
In addition, the specifically detected virus is confirmed to be localized by in situ hybridization. Serum is preserved in case a virus species that can be diagnosed by its serum antibody titer is identified. Through transcriptome analysis, we aim to elucidate the pathology by analyzing esophageal achalasia and viral infections and their regulatory molecules, focusing on the expression of various viruses including herpesvirus, especially viral microRNAs involved in latent infection and reactivation.
Quantitative analysis of herpesvirus microRNA expression in the esophageal muscle layer of patients with esophageal achalasia or achalasia-related disease.
Transcriptome analysis of infectious virus species and their regulatory molecules in the esophageal muscle layer of patients with esophageal achalasia or achalasia-related diseases.
Relationship between esophageal achalasia (Type I, Type II, Type III) or patients with achalasia-related diseases and viral infection in the esophageal muscle layer and its regulatory molecules and various pathological conditions.
Relationship between esophageal achalasia (Type I, Type II, Type III) or achalasia-related disease patients, identified virus species, and various pathological conditions.
Serological diagnosis of viruses that can cause esophageal achalasia and other esophageal dyskinesia.
Observational
20 | years-old | <= |
100 | years-old | >= |
Male and Female
Patients group: Showa University Koto Toyosu Hospital Gastroenterology Center, Fukuoka University Hospital, Tokyo Jikei University School of Medicine Hospital
(1) Patients over 20 years old who undergo POEM treatment for esophageal achalasia and achalasia-related diseases
(2) Patients who fully understand this research plan and can consent to it
(3) Patients who are 20 years of age or older at the time of obtaining consent
Control group: Tottori University Hospital
(1) Patients with non-esophageal movement disorders such as esophageal cancer who undergo esophagectomy
(2) Patients who fully understand this research plan and can consent to it
(3) Patients who are 20 years of age or older at the time of obtaining consent
Patients group:
(1) Patients who are judged to be ineligible to perform POEM
(2) Patients who are judged to be inappropriate by the doctor in charge (for example, patients in a significantly bad condition)
(3) Patients who cannot obtain informed consent
Control group:
Patients who cannot obtain informed consent
210
1st name | Haruhiro |
Middle name | |
Last name | Inoue |
Showa University Koto Toyosu Hospital
Digestive Diseases Center
1358577
Tokyo-to, Koto-ku, Toyosu, 5-1-38
03-6204-6000
haruinoue777@yahoo.co.jp
1st name | Yuichiro |
Middle name | |
Last name | Ikebuchi |
Tottori University Hospital
Gastroenterology
6838504
Tottori-ken, Yonago-shi, Nishi-machi 36-1
0859-38-6527
ikebu@tottori-u.ac.jp
Showa University Koto Toyosu Hospital
Tottori University Hospital
Other
Fukuoka University Hospital, Jikei University Hospital
Showa University Koto Toyosu Hospital
Tokyo-to, Koto-ku, Toyosu, 5-1-38
03-6204-6000
th_irb@ofc.showa-u.ac.jp
NO
2020 | Year | 05 | Month | 07 | Day |
Partially published
Enrolling by invitation
2018 | Year | 04 | Month | 09 | Day |
2018 | Year | 04 | Month | 09 | Day |
2024 | Year | 03 | Month | 31 | Day |
2024 | Year | 03 | Month | 31 | Day |
Currently, 101 cases are registered.
2020 | Year | 05 | Month | 07 | Day |
2023 | Year | 11 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046001
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