Unique ID issued by UMIN | UMIN000040389 |
---|---|
Receipt number | R000046090 |
Scientific Title | Efficacy and safety of early tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis |
Date of disclosure of the study information | 2020/05/13 |
Last modified on | 2020/05/13 19:23:15 |
Efficacy and safety of early tranexamic acid administration
in traumatic brain injury patients: a systematic review and meta-analysis
Efficacy and safety of early tranexamic acid administration
in traumatic brain injury patients: a systematic review and meta-analysis
Efficacy and safety of early tranexamic acid administration
in traumatic brain injury patients: a systematic review and meta-analysis
Efficacy and safety of early tranexamic acid administration
in traumatic brain injury patients: a systematic review and meta-analysis
Japan |
Traumatic brain injury
Neurosurgery | Emergency medicine |
Others
NO
The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of early TXA treatment remains unclear. This study aimed to assess the effect of early administration of TXA on clinical outcomes in patients with TBI by systematically reviewing the literature and synthesizing evidence of randomized controlled trials (RCTs).
Safety
Exploratory
Explanatory
Not applicable
Mortality
good neurological outcome rates, enlargement of bleeding, incidence of ischemia, and hemorrhagic intracranial complications.
Others,meta-analysis etc
Not applicable |
Not applicable |
Male and Female
MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo in the early phase after admission.
MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo in the early phase after admission.
1st name | Shoji |
Middle name | |
Last name | Yokobori |
Nippon Medical School
Department of Emergency and Critical Care Medicine
1138603
1-1-5 Sendagi, Bunkyo-Ku, Tokyom Japan
81338222131
shoji@nms.ac.jp
1st name | Shoji |
Middle name | |
Last name | yokobori |
Nippon Medical School
Department of Emergency and Critical Care Medicine
1138603
1-1-5 Sendagi, Bunkyo-Ku, Tokyom Japan
81338222131
shoji@nms.ac.jp
Nippon Medical School
Nippon Medical School
Other
Japan
Nippon Medical School
1-1-5 sendagi
81338222131
shoji@nms.ac.jp
NO
2020 | Year | 05 | Month | 13 | Day |
Unpublished
Preinitiation
2020 | Year | 05 | Month | 13 | Day |
2020 | Year | 05 | Month | 13 | Day |
2020 | Year | 06 | Month | 01 | Day |
Results:A total of 640 records were screened. Seven studies were included for quantitative analysis. Of 10,044 patients from seven of the included studies, 5,076 were randomly assigned to the TXA treatment group and 4,968 were assigned to placebo. In the TXA treatment group, 914 patients (18.0 %) died, while 961 patients (19.3%) died in the placebo group No significant differences between the groups in other important outcomes were also observed.
Conclusions: Early TXA treatment demonstrated a tendency to reduce head trauma-related deaths in the TBI population, with no significant incidence of thromboembolic events. TXA treatment may therefore be suggested in the initial TBI care.
2020 | Year | 05 | Month | 13 | Day |
2020 | Year | 05 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046090
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |