Unique ID issued by UMIN | UMIN000040447 |
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Receipt number | R000046154 |
Scientific Title | Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 2: the phenotypic and biomarker signatures for healthy longevity |
Date of disclosure of the study information | 2020/05/26 |
Last modified on | 2020/05/19 13:43:46 |
Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 2: the phenotypic and biomarker signatures for healthy longevity
Japan Centenarian and Semi-supercentenarian Study Part 2 (biomarker study)
Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 2: the phenotypic and biomarker signatures for healthy longevity
Japan Centenarian and Semi-supercentenarian Study Part 2 (biomarker study)
Japan |
healthy longevity
Medicine in general | Cardiology | Endocrinology and Metabolism |
Nephrology | Neurology | Geriatrics |
Psychiatry | Adult |
Others
YES
The aim of this study is to identify blood biomarkers, intestinal and oral flora, and life style factors which contribute to healthy longevity by using bioresources and deep phenotyping of centenariansand semi-supercentenarians. These phenotypic data are combined with genetic information obtained from Japan Centenarian and Semi-supercntenarian Study Part 1 to examine gene-environmental interaction.
Others
The identification of protective molecules and intestinal flora, and life style factors for age-related diseases such as dementia and frailty.
all cause and cause-specific mortality
incident disability, dementia, and chronic disease of aging
Observational
100 | years-old | <= |
125 | years-old | >= |
Male and Female
Centenarians: those who ages between 100 and 104 years old at enrollment
Semi-supercentenarians: those who ages 105 years and older at enrollment.
There is no upper limit for age at enrollment.
Too frail or ill to participate
1700
1st name | Yasumichi |
Middle name | |
Last name | Arai |
Keio University School of Medicine
Center for Supercentenarian Medical Research
160-8582
35, Shinanomachi, Shinjuku-ku, Tokyo, Japan
81352692468
yasumich@keio.jp
1st name | Yasumichi |
Middle name | |
Last name | Arai |
Keio University School of Medicine
Center for Supercentenarian Medical Research
160-8582
35, Shinanomachi, Shinjuku-ku, Tokyo, Japan
81352692468
http://www.keio-centenarian.com/
yasumich@keio.jp
Keio University School of Medicine
Japan Agency for Medical Research and development (AMED)
Japanese Governmental office
Japan
Keio Global Research Institute, Keio University
Ministry of Education, Culture, Sports, Science and Technology
Ministry of Health, Labor and Welfare
Ministry of Agriculture, Forestry, and Fisheries
the Ethics committee of the Keio University School of Medicine
35, Shinanomachi, Shinjuku-ku, Tokyo, Japan
81353633503
med-rinri-jimu@adst.keio.ac.jp
NO
慶應義塾大学医学部(東京都)
2020 | Year | 05 | Month | 26 | Day |
Partially published
930
In a cohort of 1554 individuals including 684 centenarians and semi-supercentenarians, inflammation predicted all-cause mortality in the very old and semi-supercentenarians. Inflammation predicted capability and cognition in (semi-)supercentenarians, suggesting suppression of age-related inflammatory activation is the key to healthy longevity.
2020 | Year | 05 | Month | 19 | Day |
2005 | Year | 08 | Month | 10 | Day |
Centenarians, semi-supercentenarians and their offspring and unrelated family living in Japan are enrolled in this study.
Most of centenarians are female, and characterized by low prevalence of diabetes.
A toatal of 304 centenarians living in Tokyo (65 men, 239 women) were enrolled in the Tokyo Centenarian Study between 2000-2002.
Subsequently, more than 600 semi-supercentenarians living in the whole country in Japan has been recruited for the Japan Semi-supercentenarian Study (JSS) since 2002. The recruitment of JSS is still opening.
Vital status of the study participants are followed annually by telephone of mail.
none
1. all-cause and cause^specific mortality
2. Incidental disability, dementia, and age-related diseases.
The datasets of centenarians have ethical and legal restrictions for public deposition due to the inclusion of sensitive information from a vulnerable population.
The datasets of centenarians have ethical and legal restrictions for public deposition due to the inclusion of sensitive information from a vulnerable population. The data will be available upon request with an appropriate research arrangement with approval of the Research Ethics Committee of Keio University School of Medicine for Clinical Research.
Open public recruiting
2000 | Year | 04 | Month | 01 | Day |
2000 | Year | 04 | Month | 21 | Day |
2000 | Year | 07 | Month | 01 | Day |
2024 | Year | 03 | Month | 31 | Day |
2024 | Year | 03 | Month | 31 | Day |
2024 | Year | 03 | Month | 31 | Day |
2025 | Year | 03 | Month | 31 | Day |
This is a part of observational studies of centenarians and semi-supercentenarians living n Japan, which aims to identify blood biomarkers and life style factors conductive to healthy longevity, and predictors of exceptional survival.
2020 | Year | 05 | Month | 19 | Day |
2020 | Year | 05 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046154
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