Unique ID issued by UMIN | UMIN000040959 |
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Receipt number | R000046776 |
Scientific Title | Cerebral lateralization of ankle joint position sense in healthy left- and right-side dominant adults studied by functional magnetic resonance imaging |
Date of disclosure of the study information | 2020/08/01 |
Last modified on | 2021/02/09 12:36:36 |
Cerebral lateralization of ankle joint position sense in healthy left- and right-side dominant adults studied by functional magnetic resonance imaging
MRIJPS
Cerebral lateralization of ankle joint position sense in healthy left- and right-side dominant adults studied by functional magnetic resonance imaging
MRIJPS
Japan |
Healthy people
Medicine in general | Neurology | Adult |
Others
NO
We aim to comprehensively study the neural and behavioral correlates during ankle joint position sense (JPS) tasks in strongly right- or left-side dominant subjects to better understand how the brain processes the lower limbs position sense information.
Others
First, we will examine the laterality of the foot proprioceptive representation in the left-handed participants using two tasks, namely ipsilateral (i.e., memory-based) and contralateral (i.e., interhemispheric transfer) matching tasks to address controversy on their decreased laterality. Second, the degree of proprioceptive laterality in left-handed is going to be compared with that of laterality in other domains, namely the language and face processing to explore the potential common neural foundation of functional laterality across different cognitive domains. Finally, we will explore if such neural laterality in these domains is associated with the individual difference in the high-level social cognitive domain, specifically, the self-transcendence personality trait.
Exploratory
Explanatory
Not applicable
We will adopt a conventional two-level approach for a block-design fMRI data using SPM12. A voxel-by-voxel multiple regression analysis will be conducted for the first-level within-subject (fixed effects) model. We will construct for each subject a model of expected signal changes involving the four conditions; 2 measurement conditions(ipsilateral/contralateral) by 2 foot-laterality conditions(right/left).
Any deviation from the target position, discounting direction, was defined as the absolute position error:
1) E absolute = ABS(Xparticipant - Xtarget)
For constant error, the difference between reproduced and actual target angle was used, considering the direction of the error:
2) E constant = ( Xparticipant - Xtarget )
3) E variable: The variable error was calculated as the overall standard deviation (SD) of constant error from 14 trials, irrespective of the target range:
Interventional
Cross-over
Randomized
Individual
Single blind -participants are blinded
Active
NO
NO
Institution is considered as a block.
NO
Numbered container method
3
Educational,Counseling,Training
Behavior,custom |
Unilateral and bilateral active motor tasks:
Ipsilateral matching task:
Contralateral matching task:
20 | years-old | <= |
40 | years-old | >= |
Male and Female
healthy participants
more than 20 years old
left- and right-side dominant
history of neurological or orthopaedic disorders
other diseases
injury
claustrophobia
anything against performing MRI
40
1st name | Ryoichi |
Middle name | |
Last name | Nagatomi |
Tohoku University
Division of Biomedical Engineering for Health & Welfare
980-8575
2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
8122-717-8588
nagatomi@med.tohoku.ac.jp
1st name | Ryoichi |
Middle name | |
Last name | Nagatomi |
Tohoku University
Division of Biomedical Engineering for Health & Welfare
980-8575
2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
8122-717-8588
nagatomi@med.tohoku.ac.jp
Tohoku University
Tohoku University
Self funding
Ethics Committee Tohoku University Graduate School of Medicine
Seiryo-machi 2-1, Aoba-ku, Sendai
022-717-8007
med-kenkyo@grp.tohoku.ac.jp
NO
2020 | Year | 08 | Month | 01 | Day |
Unpublished
Preinitiation
2020 | Year | 08 | Month | 01 | Day |
2020 | Year | 09 | Month | 18 | Day |
2021 | Year | 04 | Month | 01 | Day |
2022 | Year | 03 | Month | 31 | Day |
2020 | Year | 06 | Month | 30 | Day |
2021 | Year | 02 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046776
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