Unique ID issued by UMIN | UMIN000041143 |
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Receipt number | R000046965 |
Scientific Title | 3D ultrasonography for intestinal fibrosis in Crohn's disease |
Date of disclosure of the study information | 2020/08/10 |
Last modified on | 2024/02/10 18:50:29 |
Can 3D ultrasonography evaluate fibrosis in Crohn's disease
3D ultrasonography for Crohn's disease
3D ultrasonography for intestinal fibrosis in Crohn's disease
3D ultrasonography for Crohn's disease
Japan |
Crohn's disease
Gastroenterology |
Others
NO
Crohn's disease (CD) is an idiopathic, chronic entelitis with transmural inflammation that results in intestinal stricture. There are two types of stricture: inflammatory stricture caused by edema and fibrotic stricture caused by fibrosis. It is desirable to establish imaging studies. In the present study, we will investigate the association between ultrasonographic pamameters such as wall thickening, increased blood flow, tissue elasticity, and histopathological fingings (fibrosis, inflammation, edema), and immunological findings (angiogenesis, inflammatory cell infiltration, cytokines and growth factors).
Safety
Exploratory
Pragmatic
Not applicable
Primary outcome is to evaluate the usefulness of 3D ultrasound parameters (wall thickening, blood flow, and elasticity) as a method to differentiate between inflammatory and fibrotic stenoses that occur in Crohn's disease.
Secondary outcome is to explore the immunological abnormalities that cause fibrosis by monitoring the immune abnormalities that cause stenosis by ultrasound.
Observational
15 | years-old | <= |
Not applicable |
Male and Female
Patients with CD who undergo CD-related surgery or MR enterography
1. Lesions that did not undergo intestinal resection, such as strictureplasty
2. When the principal investigator considered not suitable.
80
1st name | Shintaro |
Middle name | Sagami |
Last name | Sagami |
Kitasato University Kitasato Institute Hospital
Department of gastroenterology
108-8642
5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan
03-3444-6161
sagami@insti.kitasato-u.ac.jp
1st name | Shintaro |
Middle name | Sagami |
Last name | Sagami |
Kitasato University Kitasato Institute Hospital
Center for Advanced IBD Research and Treatment
108-8642
5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan
03-3444-6161
sagami@insti.kitasato-u.ac.jp
Kitasato University Kitasato Institute Hospital
KAKEN: 20K16707
Japanese Governmental office
Research Ethics Committee, Kitasato University Kitasato Research Institute Hospital
5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan
03-3444-6161
kenkyu@insti.kitasato-u.ac.jp
NO
2020 | Year | 08 | Month | 10 | Day |
Unpublished
Open public recruiting
2020 | Year | 07 | Month | 20 | Day |
2020 | Year | 08 | Month | 05 | Day |
2020 | Year | 08 | Month | 10 | Day |
2024 | Year | 03 | Month | 31 | Day |
Recruitment of target people: patients who receive Crohn's disease related-surgery or MR enterography in Kitasato University Kitasato Institute Hospital between 10th August 2018 and 31th Mar. 2024.
2020 | Year | 07 | Month | 17 | Day |
2024 | Year | 02 | Month | 10 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046965
Research Plan | |
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2024/02/10 | 研究計画書_3DUS_v3.docx |
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