Unique ID issued by UMIN | UMIN000041427 |
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Receipt number | R000047297 |
Scientific Title | Prognostic role of simple coagulation profiles in predicting in-hospital mortality of COVID-19 patients: a meta-analysis |
Date of disclosure of the study information | 2020/08/16 |
Last modified on | 2020/10/11 16:31:13 |
Prognostic role of simple coagulation profiles in predicting in-hospital mortality of COVID-19 patients: a meta-analysis
Prognostic role of simple coagulation profiles in predicting in-hospital mortality of COVID-19 patients: a meta-analysis
Prognostic role of simple coagulation profiles in predicting in-hospital mortality of COVID-19 patients: a meta-analysis
Prognostic role of simple coagulation profiles in predicting in-hospital mortality of COVID-19 patients: a meta-analysis
Asia(except Japan) |
COVID-19
Medicine in general | Cardiology | Pneumology |
Hematology and clinical oncology | Infectious disease | Laboratory medicine |
Intensive care medicine |
Others
NO
we perform this meta-analysis aims to determine the evidence-based relationship of Coagulation profiles with in-hospital mortality in COVID-19 patients
Others
relationship to predict outcome
Coagulation profiles level (aPTT, PT, Platelet, INR) on admission based on mortality of the case
Others,meta-analysis etc
18 | years-old | <= |
80 | years-old | >= |
Male and Female
all observational studies or trials that involving adult patients with COVID-19 that had any data of coagulation profiles (aPTT, PT, Platelet, INR) on admission for comparison survivor vs non-survivor
missing required data,
coagulation profiles sampling was not on admission
no outcome of interest
1st name | Johanes |
Middle name | |
Last name | Nugroho |
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Department of Cardiology and Vascular Medicine
60131
Jl. Mayjen Prof. Dr. Moestopo 47
6282139090953
j.nugroho.eko@fk.unair.ac.id
1st name | Eka |
Middle name | Prasetya Budi |
Last name | Mulia |
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Department of Cardiology and Vascular Medicine
60131
Jl. Mayjen Prof. Dr. Moestopo 47
628562765365
https://www.researchgate.net/profile/Eka_Mulia
eka.prasetya.budi-2017@fk.unair.ac.id
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
None
Government offices of other countries
Komite Etik Penelitian Kesehatan RSUD Dr Soetomo, Surabaya, Indonesia
Jalan Mayjen. Prof. Dr. Moestopo No. 6-8, Surabaya, Jawa Timur 60286
0315501011
kontak@rsudrsoetomo.jatimprov.go.id
NO
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2020 | Year | 08 | Month | 16 | Day |
Unpublished
5327
Our meta-analysis showed that non-survivor group had lower platelet count compared to survivor group (SMD=-0.71 [95% CI: -1.01 to -0.41], p<0.001; OR=3.89 [95%CI: 1.71 to 8.85], p=0.001); prolong PT (SMD=0.89 [95%CI: 0.35 to 1.43], p=0.001; OR=2.49 [95%CI: 1.00 to 6.20], p=0.05); prolong aPTT (SMD=0.33 [95%CI: -0.10 to 0.75], p=0.13); and increased INR (SMD=2.21 [95%CI: 0.10 to 4.31], p=0.04).
2020 | Year | 10 | Month | 11 | Day |
Completed
2020 | Year | 07 | Month | 01 | Day |
2020 | Year | 07 | Month | 10 | Day |
2020 | Year | 07 | Month | 16 | Day |
2020 | Year | 09 | Month | 15 | Day |
2020 | Year | 09 | Month | 15 | Day |
2020 | Year | 09 | Month | 15 | Day |
2020 | Year | 09 | Month | 20 | Day |
We perform this meta-analysis aims to determine the evidence-based relationship of Coagulation profiles with mortality in COVID-19 patients
A systematic search of all observational studies or trials that involving adult patients with COVID-19 that had any data of Coagulation profiles (fibrinogen, fibrin degradation product, anti-thrombin, thrombin time, aPTT, PT, D-dimer, Platelet, INR) on admission for comparison survivor vs non-survivor was carried out using the PubMed, Science Direct and MedRxiv databases. Two authors independently assessed the methodological quality using the NIH quality assessment to evaluate the quality of evidence. We performed random-effects inverse-variance weighted meta-analysis of Coagulation profiles values using RevMan 5.4. Manager (RevMan v5.4 2020) and Stata v.16
2020 | Year | 08 | Month | 16 | Day |
2020 | Year | 10 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047297
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