Unique ID issued by UMIN | UMIN000041491 |
---|---|
Receipt number | R000047370 |
Scientific Title | The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI |
Date of disclosure of the study information | 2020/08/21 |
Last modified on | 2020/08/21 02:04:20 |
The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI
The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI
The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI
The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI
Japan |
Leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, malignant lymphoma, multiple myeloma
Hematology and clinical oncology |
Malignancy
NO
We evaluate the dynamics of homing, engraftment, hematopoiesis and immune reconstitution used by 18F-FLT PET/MRI in allogeneic HCT patients. We analyze the influence of stem cell source, HLA mismatch, disease status, conditioning and GVHD prophylaxis on hematopoiesis process.
Others
We evaluate the dynamics of homing, engraftment, hematopoiesis and immune reconstitution used by 18F-FLT PET/MRI in allogeneic HCT patients. We analyze the influence of stem cell source, HLA mismatch, disease status, conditioning and GVHD prophylaxis on hematopoiesis process.
The primary endpoint is to access the characteristics of hematopoiesis process in BM, PB and CB transplantation patients. We evaluate regularly the standardized uptake value of whole-body bone marrow used by 18F-FLT PET/MRI during the pretransplant and first posttransplant year.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Device,equipment |
We evaluate 18F-FLT PET/MRI during the phase of pretransplant, engraftment and posttransplant day +180. We also evaluate whole bone marrow MRI in the posttransplant day +100 and +365.
20 | years-old | <= |
Not applicable |
Male and Female
1 Patients aged 20 years or older at the time of obtaining consent
2 Hematological malignancy (Leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, malignant lymphoma and multiple myeloma) patients who receive allogeneic hematopoietic cell transplantation
3 Patients who, after receiving a sufficient explanation for participating in this study, have a sufficient understanding and have the free written consent of the patient (or a deputy if a deputy is required)
1 Patients who have Surgically implanted medical devices in the body (cardiac pacemaker, cochlear implant,
vascular stent, arterial clip, prosthetic joint, dental implant, magnetic dentures, etc.)
2 Pregnant women or patients who may be pregnant
3 Other patients who the investigator determined to be inappropriate as subjects
30
1st name | Takahiro |
Middle name | |
Last name | Yamauchi |
University of Fukui Hospital
Department of hematology and oncology
910-1193
23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui
+81-776-61-3111
araie116@u-fukui.ac.jp
1st name | Hiroaki |
Middle name | |
Last name | Araie |
University of Fukui Hospital
Department of hematology and oncology
910-1193
23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui
+81-776-61-3111
araie116@u-fukui.ac.jp
University of Fukui
University of Fukui Hospital
Department of hematology and oncology
Biomedical imaging research center
Self funding
The Research Ethics Committee of University of Fukui
23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui
+81-776-61-3111
sm-kenkyusien@ml.u-fukui.ac.jp
NO
2020 | Year | 08 | Month | 21 | Day |
Unpublished
Enrolling by invitation
2020 | Year | 07 | Month | 14 | Day |
2020 | Year | 07 | Month | 27 | Day |
2020 | Year | 08 | Month | 14 | Day |
2025 | Year | 03 | Month | 31 | Day |
2020 | Year | 08 | Month | 21 | Day |
2020 | Year | 08 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047370
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |