Unique ID issued by UMIN | UMIN000041685 |
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Receipt number | R000047568 |
Scientific Title | Analysis of characteristic skin composition in children with atopic dermatitis using in vivo confocal Raman spectroscopy |
Date of disclosure of the study information | 2020/09/08 |
Last modified on | 2023/11/29 10:04:55 |
Analysis of characteristic skin composition in children with atopic dermatitis
Analysis of skin composition
Analysis of characteristic skin composition in children with atopic dermatitis using in vivo confocal Raman spectroscopy
Analysis of skin composition
Japan |
non-atopic volunteer, atopic dermatitis
Dermatology | Child |
Others
NO
To investigate skin composition (amount of water, natural moisturizing factor, cholesterol, ceramide, etc.) in children with atopic dermatitis using in vivo confocal Raman spectroscopy, and to clarify the skin composition related to the skin barrier function
Others
Exploratory cross-sectional study
Exploratory
Not applicable
Skin parameters (amount of water, natural moisturizing factor, cholesterol, ceramide, etc.) assessed by in vivo confocal Raman spectroscopy and skin measuring equipment
1.Age-stratified analysis of skin parameters(2-5 years old, 6-10 years old)
2. Correlation between skin composition detected by in vivo confocal Raman spectroscopy and skin parameters measured by skin measuring equipment or dermatological findings
3. Filaggrin and filaggrin-degrading enzymes in the stratum corneum
Observational
2 | years-old | <= |
11 | years-old | > |
Male and Female
1)Children aged 2 to 10 years old at the time of obtaining informed consent
2)
i)Atopic dermatitis patients
a. Mild to moderate atopic dermatitis (EASI: 1.1 to 21.0)
b. Mild to moderate skin dryness and desquamation scores on both left and right inner forearms
ii)non-atopic volunteer
a. No history of atopic dermatitis
1)Those who have a serious underlying disease requiring hospitalization
2)Those who are deemed unsuitable for inclusion in the study for any other reason by the outpatient doctors
3)
i)Atopic dermatitis patients
a. Those who get systemic therapy for atopic dermatitis (internal steroids or immunosuppressants etc.)
ii)non-atopic volunteer
a. History of allergic disease
b. Those who have dry skin
30
1st name | Kazue |
Middle name | |
Last name | Yoshida |
National Center for Child health and Development
Division of Dermatology
157-8535
2-10-1,Okura,Setagayaku,Tokyo 157-8535
03-3416-0181
skin_research@ncchd.go.jp
1st name | Risa |
Middle name | |
Last name | Fukuda |
National Center for Child health and Development
Division of Dermatology
157-8535
2-10-1,Okura,Setagayaku,Tokyo 157-8535
03-3416-0181
skin_research@ncchd.go.jp
National Center for Child health and Development
Maruho Co.,LTD.
Profit organization
National Center for Child health and Development
2-10-1,Okura,Setagayaku,Tokyo 157-8535
03-3416-0181
rinri@ncchd.go.jp
NO
2020 | Year | 09 | Month | 08 | Day |
Unpublished
No longer recruiting
2020 | Year | 07 | Month | 20 | Day |
2020 | Year | 07 | Month | 31 | Day |
2020 | Year | 09 | Month | 03 | Day |
2023 | Year | 04 | Month | 30 | Day |
In addition to the measurement of skin constituents, filaggrin in the stratum corneum and filaggrin-degrading enzyme, survey by questionnaire and photography.
2020 | Year | 09 | Month | 04 | Day |
2023 | Year | 11 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047568
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