Unique ID issued by UMIN | UMIN000042878 |
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Receipt number | R000048940 |
Scientific Title | Investigation of Association between Kawasaki Disease and Yersinia Infection |
Date of disclosure of the study information | 2021/01/01 |
Last modified on | 2024/01/04 12:47:57 |
Investigation of Association between Kawasaki Disease and Yersinia Infection
KD-Yersinia study
Investigation of Association between Kawasaki Disease and Yersinia Infection
KD-Yersinia study
Japan |
Kawasaki disease
Pediatrics | Child |
Others
NO
To discover the clinical characteristics of Yersinia infection manifesting Kawasaki disease-like symptoms
Others
Epidemiology
Exploratory
Pragmatic
Not applicable
The incidence of Yersinia infection among patients diagnosed with Kawasaki disease
The difference in the following characteristics between Yersinia positive patients and negative patients: duration of fever, unresponsiveness to IVIG, coronary artery lesion within 2 months from the beginning of treatment
Observational
Not applicable |
Not applicable |
Male and Female
Patients diagnosed with Kawasaki disease
Subjects who agreed, or whose parents provided consent for enrollment in the study
Subjects without stool sample
Patients considered inappropriate for enrollment by investigator
70
1st name | Hiroshi |
Middle name | |
Last name | Hayashi |
Tokyo Metropolitan Children's Medical Center
Department of General Pediatrics
183-8561
2-8-29 Musashidai, Fuchu, Tokyo, Japan
(+81)-42-300-5111
hiroshi_hayashi@tmhp.jp
1st name | Hiroshi |
Middle name | |
Last name | Hayashi |
Tokyo Metropolitan Children's Medical Center
Department of General Pediatrics
183-8561
2-8-29 Musashidai, Fuchu, Tokyo, Japan
(+81)-42-300-5111
hiroshi_hayashi@tmhp.jp
Tokyo Metropolitan Children's Medical Center
Tokyo Metropolitan Government
Local Government
Japan
Tokyo Metropolitan Children's Medical Center Clinical Research Review Board
2-8-29 Musashidai, Fuchu, Tokyo, Japan
(+81) -42-300-5111
sn_rinri@tmhp.jp
YES
2020b-123
Tokyo Metropolitan Children's Medical Center
東京都立小児総合医療センター(東京都)/ Tokyo Metropolitan Children's Medical Center (Tokyo)
2021 | Year | 01 | Month | 01 | Day |
https://journals.lww.com/pidj/abstract/2023/12000/association_of_yersinia_infection_with_kawasaki.3.
Published
https://journals.lww.com/pidj/abstract/2023/12000/association_of_yersinia_infection_with_kawasaki.3.
117
During the study period, 141 KD patients were screened and 117 patients with evaluable stool samples were registered. Only 1 patient was positive for Yersinia pseudotuberculosis, which was detected from both stool and blood cultures. The patient was refractory to KD treatment but improved after initiation of appropriate antibiotic therapy.
2024 | Year | 01 | Month | 04 | Day |
The median age was 2.2 years, and more male patients than female patients were included. All the patients had a fever and elevated inflammatory markers. IVIG therapy was given to 98% of the patients, and 23% were refractory to primary IVIG therapy and received second-line treatment.
During the study period, 141 KD patients were enrolled. Among these, 24 patients who did not have a stool culture were excluded. A total of 117 eligible patients were included in the analysis.
No
Number of Yersinia positive patients
Main results already published
2020 | Year | 12 | Month | 01 | Day |
2020 | Year | 12 | Month | 14 | Day |
2021 | Year | 01 | Month | 08 | Day |
2022 | Year | 03 | Month | 31 | Day |
The difference in the following characteristics between Yersinia positive patients and negative patients: duration of fever, unresponsiveness to IVIG, coronary artery lesion within 2 months from the beginning of treatment.
2020 | Year | 12 | Month | 30 | Day |
2024 | Year | 01 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048940
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