Unique ID issued by UMIN | UMIN000043310 |
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Receipt number | R000049451 |
Scientific Title | The efficacy of low-dose macrolides for severe asthma in clinical practice |
Date of disclosure of the study information | 2021/02/12 |
Last modified on | 2024/02/15 12:20:04 |
The efficacy of low-dose macrolides for severe asthma in clinical practice
The efficacy of low-dose macrolides for severe asthma in clinical practice
The efficacy of low-dose macrolides for severe asthma in clinical practice
The efficacy of low-dose macrolides for severe asthma in clinical practice
Japan |
asthma
Pneumology |
Others
NO
To investigate the efficacy of macrolides for asthma exacerbation
Efficacy
The number of annual exacerbations before and after the administration of long-term macrolide therapy
Observational
16 | years-old | <= |
Not applicable |
Male and Female
1) Asthma patients continuously treated from 2018/3/1 to 2020/9/30 in the department of Respiratory Medicine in National Center for Global Health and Medicine.
2) Asthma patients who received treatment equivalent to Global Initiative for Asthma (GINA) Step 4/5.
3) Asthma patients whose asthma exacerbations requiring systemic steroid was retrospectively trackable in their medical records.
1) Asthma patients who started or discontinued macrolides for their asthma during 2018/3/1-2020/9/30.
2) Other unsuitable conditions
385
1st name | Motoyasu |
Middle name | |
Last name | Iikura |
National Center for Global Health and Medicine
Department of Respiratory Medicine
1628655
1-21-1, Toyama, Shinjuku-ku, Tokyo, JAPAN
03-3202-7181
iimotoya@hosp.ncgm.go.jp
1st name | Naoko |
Middle name | |
Last name | Nagano |
National Center for Global Health and Medicine
Department of Respiratory Medicine
1628655
1-21-1, Toyama, Shinjuku-ku, Tokyo, JAPAN
03-3202-7181
matsunao28@yahoo.co.jp
National Center for Global Health and Medicine
National Center for Global Health and Medicine
Self funding
Certified Review Board of National Center for Global Health and Medicine
1-21-1, Toyama, Shinjuku-ku, Tokyo, JAPAN
03-3202-7181
kenkyu-shinsa@hosp.ncgm.go.jp
NO
2021 | Year | 02 | Month | 12 | Day |
https://center6.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000049451
Unpublished
https://center6.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000049451
385
Of the 371 patients who met inclusion criteria, 23 were on macrolides and 348 were not. Patients on macrolides had higher GINA Steps and more sinusitis complications than those on macrolide days.
In a sample of 14 patients who had been on macrolides for at least 12 months, the median number of annual exacerbations dropped from 1 to 0 when comparing the number of exacerbations in the year before and after macrolide initiation (p = 0.042).
2024 | Year | 02 | Month | 15 | Day |
Patients with severe asthma (GINA step 4/5) who had been continuously attending the Department of Respiratory Medicine, National Center for Global Health and Medicine for one year from March 1, 2018 to February 28, 2019.
*Excludes cases in which macrolides were started or discontinued during the observation period.
Patients with severe asthma (GINA step 4/5) who had been continuously attending the Department of Respiratory Medicine, National Center for Global Health and Medicine for one year from March 1, 2018 to February 28, 2019.
*Excludes cases in which macrolides were started or discontinued during the observation period.
Nothing particular.
The clinical characteristics of patients treated with macrorides and the effect of long-term macrolide administration on asthma exacerbations
Completed
2020 | Year | 11 | Month | 01 | Day |
2021 | Year | 01 | Month | 08 | Day |
2020 | Year | 11 | Month | 01 | Day |
2021 | Year | 03 | Month | 31 | Day |
Clinical characteristics, treatment, and the number of exacerbations were reviewed in eligible asthma patients.
2021 | Year | 02 | Month | 12 | Day |
2024 | Year | 02 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049451
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