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Name:
UMIN ID:

Recruitment status Preinitiation
Unique ID issued by UMIN UMIN000043347
Receipt No. R000049492
Scientific Title A systematic review of mitochondrial transplantation therapy on ischemia reperfusion injury
Date of disclosure of the study information 2021/02/17
Last modified on 2021/02/17

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Basic information
Public title A systematic review of mitochondrial transplantation therapy on ischemia reperfusion injury
Acronym A systematic review of mitochondrial transplantation therapy on ischemia reperfusion injury
Scientific Title A systematic review of mitochondrial transplantation therapy on ischemia reperfusion injury
Scientific Title:Acronym A systematic review of mitochondrial transplantation therapy on ischemia reperfusion injury
Region
North America

Condition
Condition Critical illness
Classification by specialty
Medicine in general Surgery in general Neurosurgery
Cardiovascular surgery Laboratory medicine Emergency medicine
Intensive care medicine
Classification by malignancy Others
Genomic information NO

Objectives
Narrative objectives1 The purpose of this systematic review is to undertake a systematic review of relevant animal and human studies to summarize current evidence of mitochondrial transplantation as a novel therapeutic strategy on ischemia reperfusion injury under critical illness.

P: Ischemia reperfusion injury
I: Mitochondrial transplantation
O: Biological or physiological measures of the ischemia reperfusion injury.
S: RCT, other intervention studies, cohort studies, animal studies
Basic objectives2 Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase

Assessment
Primary outcomes Biological or physiological measures of the ischemia reperfusion injury.
Key secondary outcomes

Base
Study type Others,meta-analysis etc

Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment

Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10

Eligibility
Age-lower limit

Not applicable
Age-upper limit

Not applicable
Gender Male and Female
Key inclusion criteria P: Critical illness related to ischemia reperfusion injury including myocardial infarction, organ transplantation, cardiac arrest, and acute brain injury.
I: Intraarterial or intravenous injection, or direct injection into the region at risk with isolated mitochondria.
O: Biological or physiological measures of the ischemia reperfusion injury.
S: RCT, other intervention studies, cohort studies, animal studies

1. Studies published in peer-reviewed journals.
2. Studies published as research papers which enabled to obtain a full text.
Key exclusion criteria 1. Studies that used a mesenchymal stem cell-mediated transfer of mitochondria as a transfer method
2. Studies under cell culture conditions
Target sample size

Research contact person
Name of lead principal investigator
1st name Kei
Middle name
Last name Hayashida
Organization Feinstein Institutes for Medical Research
Division name Emergency medicine
Zip code 11030
Address 350 Community Drive, Manhasset, NY
TEL 1-516-562-1305
Email keilinda0714@gmail.com

Public contact
Name of contact person
1st name Kei
Middle name
Last name Hayashida
Organization Feinstein Institutes for Medical Research
Division name Emergency medicine
Zip code 11030
Address 350 Community Drive, Manhasset, NY
TEL 1-516-562-1305
Homepage URL
Email keilinda0714@gmail.com

Sponsor
Institute Feinstein Institutes for Medical Research
Institute
Department

Funding Source
Organization Feinstein Institutes for Medical Research
Organization
Division
Category of Funding Organization Outside Japan
Nationality of Funding Organization

Other related organizations
Co-sponsor
Name of secondary funder(s)

IRB Contact (For public release)
Organization Feinstein Institutes for Medical Research
Address Emergency medicine
Tel 1-516-562-1305
Email keilinda0714@gmail.com

Secondary IDs
Secondary IDs NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW

Institutions
Institutions

Other administrative information
Date of disclosure of the study information
2021 Year 02 Month 17 Day

Related information
URL releasing protocol
Publication of results Unpublished

Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description

Progress
Recruitment status Preinitiation
Date of protocol fixation
2021 Year 02 Month 17 Day
Date of IRB
Anticipated trial start date
2021 Year 02 Month 17 Day
Last follow-up date
2021 Year 02 Month 17 Day
Date of closure to data entry
Date trial data considered complete
Date analysis concluded

Other
Other related information Systematic review

Management information
Registered date
2021 Year 02 Month 17 Day
Last modified on
2021 Year 02 Month 17 Day


Link to view the page
URL(English) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049492

Research Plan
Registered date File name

Research case data specifications
Registered date File name

Research case data
Registered date File name


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