Unique ID issued by UMIN | UMIN000043447 |
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Receipt number | R000049614 |
Scientific Title | Differential effects of propofol and remimazolam on heart rate variability during anesthetic induction |
Date of disclosure of the study information | 2021/03/01 |
Last modified on | 2022/02/27 09:40:04 |
Effects of remimazolam on heart rate variability
Effects of remimazolam on heart rate variability
Differential effects of propofol and remimazolam on heart rate variability during anesthetic induction
Differential effects of propofol and remimazolam on heart rate variability during anesthetic induction
Japan |
The patients who receive general anesthesia
Anesthesiology |
Others
NO
To elucidate the effects of remimazolam on autonomic nerve activity using a heart rate variability analysis.
Pharmacodynamics
Confirmatory
Explanatory
Not applicable
Changes in heart rate variability before and after anesthetic induction with propofol or remimazolam
Changes in blood pressure and heart rate before and after anesthetic induction with propofol for remimazolam
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Active
NO
NO
Institution is not considered as adjustment factor.
NO
Central registration
2
Treatment
Medicine |
Surgical patients were randomized to remimazolam started at 12 mg/kg/h by continuous intravenous (IV) infusion until the loss of consciousness (LoC), followed by 1 mg/kg/h to be adjusted as appropriate until the end of surgery
Surgical patients were randomized to propofol started at 0.05mL/kg/10s by continuous intravenous (IV) infusion until the loss of consciousness (LoC), followed by 1.0 mL/kg/h to be adjusted as appropriate until the end of surgery.
18 | years-old | <= |
65 | years-old | > |
Male and Female
Relevant inclusion criteria included over 18 years old, a bodyweight of 100 kg or less, scheduled for elective surgery requiring tracheal intubation and an American Society
of Anesthesiologists physical status of 1 or 2
Key exclusion criteria included emergency surgeries or
patients with consciousness disturbance, drug dependence, alcohol dependence, uncontrolled hypertension, acute angle-closure glaucoma, myasthenia gravis, renal failure, massive hemorrhage, shock and pregnant and nursing women.
30
1st name | Naoyuki |
Middle name | |
Last name | Hirata |
Sapporo Medical University School of Medicine
Department of Anesthesiology
060-8543
S1, W16, Chuo-ku, Sapporo
011-611-2111
naohirata@mac.com
1st name | Naoyuki |
Middle name | |
Last name | Hirata |
Sapporo Medical University School of Medicine
Department of Anesthesiology
060-8543
S1, W16, Chuo-ku, Sapporo
011-611-2111
naohirata@mac.com
Sapporo Medical University School of Medicine
Self funding
Self funding
Sapporo Medical University School of Medicne
S1, W16, Chuo-ku, Sapporo
011-611-2111
ji-rskk@sapmed.ac.jp
NO
2021 | Year | 03 | Month | 01 | Day |
Published
https://link.springer.com/article/10.1007/s00540-022-03037-8
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2022 | Year | 01 | Month | 13 | Day |
Completed
2021 | Year | 02 | Month | 12 | Day |
2021 | Year | 02 | Month | 12 | Day |
2021 | Year | 03 | Month | 01 | Day |
2022 | Year | 03 | Month | 31 | Day |
2021 | Year | 02 | Month | 26 | Day |
2022 | Year | 02 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049614
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