Unique ID issued by UMIN | UMIN000043656 |
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Receipt number | R000049856 |
Scientific Title | Decongestion in patients with heart failure by sacubitrill-valsartan |
Date of disclosure of the study information | 2021/03/18 |
Last modified on | 2021/03/18 09:03:23 |
Decongestion in patients with heart failure by sacubitrill-valsartan
DRY-START trial
Decongestion in patients with heart failure by sacubitrill-valsartan
DRY-START trial
Japan |
heart failure with congestion
Cardiology |
Others
NO
The efficacy of sacubitrill-valsartan for the patients with heart failure with preserved ejection fraction
Efficacy
The improvement of congestion evaluated by transthoracic echocardiography at 6 month
The improvement of congestion evaluated by transthoracic echocardiography at 12 month
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Sacvitrill-valsartan
12 month
maximum dose if tolerant
enarapril or valsartan
12 month
maximum dose if tolerant
20 | years-old | <= |
100 | years-old | > |
Male and Female
The patients who have acute decompensated heart failure with NT-pro BNP more than 200pg/ml(sinus), 600pg/ml(AF).
The transthoracic echocardiography shows congestion and EF>40% at discharge.
EF<40% or TTE does not show congestion
severe valvular disease
congenital heart disease
constrictive pericarditis
systolic blood pressure<110mmHg
eGFR<30ml/min/1.73m2
K>5.2mmol/L
Patients who does not take ACE-I/ARB or who can not take them.
life expectancy < 6 months due to non-cardiovascular diseases
100
1st name | masami |
Middle name | |
Last name | nishino |
Osaka Rosai Hospital
cardiology
591-8025
3069-1 Nagasone-cho, Kita-ku, Sakai-shi, Osaka
072-252-3561
mnishino@osakah.johas.go.jp
1st name | yutaka |
Middle name | |
Last name | matsuhiro |
osaka rosai hospital
cardiology
591-8025
3069-1 Nagasone-cho, Kita-ku, Sakai-shi, Osaka
072-252-3561
junnai-hisho@osakah.johas.go.jp
osaka rosai hospital
none
Other
osaka rosai hospital
3069-1 Nagasone-cho, Kita-ku, Sakai-shi, Osaka
072-252-3561
junnai-hisho@osakah.johas.go.jp
NO
2021 | Year | 03 | Month | 18 | Day |
Unpublished
Open public recruiting
2021 | Year | 03 | Month | 01 | Day |
2021 | Year | 03 | Month | 14 | Day |
2021 | Year | 03 | Month | 18 | Day |
2026 | Year | 03 | Month | 18 | Day |
2021 | Year | 03 | Month | 18 | Day |
2021 | Year | 03 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049856
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