Unique ID issued by UMIN | UMIN000044113 |
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Receipt number | R000050371 |
Scientific Title | Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) Method for Imaging Evaluation of Large-Scale Vasculitis |
Date of disclosure of the study information | 2021/12/01 |
Last modified on | 2022/11/07 09:57:01 |
Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) Method for Imaging Evaluation of Large-Scale Vasculitis
Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) Method for Imaging Evaluation of Large-Scale Vasculitis
Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) Method for Imaging Evaluation of Large-Scale Vasculitis
Usefulness of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) Method for Imaging Evaluation of Large-Scale Vasculitis
Japan |
Large Vessels Artritis
Clinical immunology |
Others
NO
In recent years, FDG-PET/CT has been approved for the evaluation of disease activity in large vessel vasculitis, and FDG-PET/CT examinations have been performed mainly at university hospitals. In recent years, however, FDG-PET/CT has been approved for the evaluation of disease activity in large vasculitis, and FDG-PET/CT is now being performed mainly in university hospitals. However, it has not been widely used due to the lack of facilities and medical costs. In this prospective study, we evaluated the sensitivity and specificity of FDG-PET/CT and DWIBS using MRI (DWIBS), which is less expensive than FDG-PET/CT and does not involve radiation exposure, in 40 patients with large vessel vasculitis to determine the usefulness of DWIBS for evaluating the activity of large vessel vasculitis in the future. The results of this study will be presented.
Efficacy
The relationship between FDG-PET/CT diagnosis and qualitative evaluation of DWIBS. The sensitivity, specificity, and positive/negative predictive value of DWIBS were determined for each of the four grades: grade 0 or higher, grade 1 or higher, grade 2 or higher, and grade 3 or higher.
Observational
16 | years-old | <= |
100 | years-old | > |
Male and Female
Patients diagnosed with large vessel vasculitis (Takayasu disease criteria 2, giant cell arteritis 3 classification criteria) in our department (new cases and cases under treatment)
1) Severe diabetes mellitus
2) Claustrophobia
3) Patients with metal implants in the body (metal clips in the brain, artificial heart valves, stents)
4) Patients with nail art, tattoos, etc.
5) Patients under 15 years old
6) Cases where patient consent cannot be obtained
40
1st name | Yuji |
Middle name | |
Last name | Nozaki |
Kindai University School of Medicine
Department of Hematology and Rheumatology
589-8511
Osaka-Sayama
0723660221
yuji0516@med.kindai.ac.jp
1st name | Yuji |
Middle name | Nozaki |
Last name | Nozaki |
Kinki University School of Medicine
Department of Hematology and Rheumatology
589-8511
Osaka-Sayama
0723660221
yuji0516@med.kindai.ac.jp
Kinki University School of Medicine
Kinki University School of Medicine
Self funding
Department of Hematology and Rheumatology, Kinki University School of Medicine
377-2 Ohno-Higashi
0723660221
yuji0516@med.kindai.ac.jp
NO
2021 | Year | 12 | Month | 01 | Day |
Unpublished
Open public recruiting
2021 | Year | 04 | Month | 20 | Day |
2021 | Year | 06 | Month | 10 | Day |
2021 | Year | 06 | Month | 10 | Day |
2026 | Year | 06 | Month | 10 | Day |
This study is a prospective observational study. FDG-PET/CT and DWIBS will be performed within 4 weeks of the blood test in addition to the blood tests regularly evaluated in the outpatient clinic. FDG-PET/CT and DWIBS will be performed at 24 weeks after the start of treatment to confirm the efficacy of treatment in new patients without prior treatment, although this is not mandatory.
Blood tests include CRP, ESR, IL-6, white blood cell count, Hb, and platelet count, and vasculitis symptoms are evaluated by examination and interview.
2021 | Year | 05 | Month | 05 | Day |
2022 | Year | 11 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050371
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