Unique ID issued by UMIN | UMIN000034774 |
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Receipt number | R000039582 |
Scientific Title | The effect of dentifrice component on blood flow promoting in gingiva |
Date of disclosure of the study information | 2018/11/10 |
Last modified on | 2020/05/07 13:57:09 |
The effect of dentifrice component on blood flow promoting in gingiva
The effect of dentifrice component on blood flow promoting in gingiva
The effect of dentifrice component on blood flow promoting in gingiva
The effect of dentifrice component on blood flow promoting in gingiva
Japan |
periodontitis
Dental medicine |
Others
NO
In the periodontal therapy, removal of plaque and calculus is the most important treatment. Since plaque deposits on the tooth surface in an short time, it is necessary to remove it by daily self-care by the patient himself/herself. Generally brushing is performed using a dentifrice, and recently toothpaste containing 1,2 tocoperol nicotinate (vitamin En: VEN) which has a blood flow promoting effect is commercially available.
In this study, a crossover test using VEN containing dentifrice and placebo dentifrice, which is already on the market, is carried out, and the gingival blood flow promoting action and its clinical effect are examined.
Efficacy
Changes in the color of cervical gingiva
(before treatment, after using VEN containing dentifrice and placebo dentifrice)
1. gingival index (GI)
2. plaque index (PI)
3. amount of VEFG and PGE2 in gingival crecivular fluid
(befoe treatment, after using VEN containing dentifrice and placebo dentifrice)
Interventional
Cross-over
Randomized
Individual
Open -but assessor(s) are blinded
Placebo
NO
NO
Institution is not considered as adjustment factor.
NO
Numbered container method
2
Treatment
Medicine |
Tooth brushing with dentifrice containing blood flow promoting component for 7days
Tooth brushing with placebo dentifrice for 7days
20 | years-old | <= |
100 | years-old | > |
Male and Female
1. Patients of Periodontics in Dental Hospital of Tokyo Medical and Dental University
2. 20 years and over
1. Patients suffering from infectious diseases such as hepatitis B, hepatitis C and HIV
30
1st name | Koji |
Middle name | |
Last name | Mizutani |
Tokyo Medical and Dental University
Department of Peridonotology
113-8510
1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan
0358035488
mizuperi@tmd.ac.jp
1st name | koji |
Middle name | |
Last name | Koji Mizutani |
Tokyo Medical and Dental University
Department of Peridonotology
113-8510
1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan
0358035488
mizuperi@tmd.ac.jp
Department of Periodontology, Tokyo Medical and Dental University
Sunstar Inc.
Profit organization
Sunstar Inc.
Department of Periodontology, Tokyo Medical and Dental university
1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan
03-5803-0196
mizuperi@tmd.ac.jp
NO
東京医科歯科大学歯学部附属病院
2018 | Year | 11 | Month | 10 | Day |
Unpublished
Enrolling by invitation
2018 | Year | 12 | Month | 01 | Day |
2019 | Year | 03 | Month | 18 | Day |
2019 | Year | 12 | Month | 01 | Day |
2021 | Year | 03 | Month | 31 | Day |
2018 | Year | 11 | Month | 05 | Day |
2020 | Year | 05 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000039582
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