Unique ID issued by UMIN | UMIN000035628 |
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Receipt number | R000040587 |
Scientific Title | Monitoring study of genomic mutations in patients with EGFR mutation or ALK translocation using plasma DNA |
Date of disclosure of the study information | 2019/01/23 |
Last modified on | 2023/07/28 19:07:14 |
Monitoring study of genomic mutations in patients with EGFR mutation or ALK translocation using plasma DNA
Monitoring of genomic mutations using plasma DNA
Monitoring study of genomic mutations in patients with EGFR mutation or ALK translocation using plasma DNA
Monitoring of genomic mutations using plasma DNA
Japan |
non-small-cell lung cancer
Pneumology |
Malignancy
YES
To address the association of the plasma DNA genotyping and treatment efficacy
Others
Exploratory study of the genomic mutations relevant to drug resistance
Assessment of significance of the monitoring the genomic mutations using the circulating tumor DNA
Observational
Not applicable |
Not applicable |
Male and Female
Advanced non-small-cell lung cancer patients harboring EGFR mutation or ALK translocation
None
100
1st name | Yasuhiro |
Middle name | |
Last name | Koh |
Wakayama Medical University
Internal Medicine III
641-8509
811-1 Kimiidera Wakayama
073-441-0619
ykoh@wakayama-med.ac.jp
1st name | Yasuhiro |
Middle name | |
Last name | Koh |
Wakayama Medical University
Internal Medicine III
641-8509
811-1 Kimiidera Wakayama
073-441-0619
ykoh@wakayama-med.ac.jp
Wakayama Medical University
Wakayama Medical University
Other
Wakayama Medical University
8-1-1 Kimiidera, Wakayama
0734410619
wa-rinri@wakayama-med.ac.jp
NO
2019 | Year | 01 | Month | 23 | Day |
None
Unpublished
None
100
Plasma DNAs were collected from patietns with non-small cell lung cancer harboring EGFR mutations or ALK rearrangement. Paired samples such as at baseline and at progressive disease were collected. Next generation sequencing was performed to detect cancer-related somatic mutations using the plasma DNA including EGFR mutations and ALK rearrangement. We were able to track the changes in the variant allele frequency of those genes and identify the potential gene mutations responsible for drug resistance.
2023 | Year | 01 | Month | 30 | Day |
Non-small cell lung cancer harboring EGFR mutations or ALK rearrangement
Written informed consent was obtained from non-small lung cancer patients harboring EGFR mutatinos or ALK rearrangement after the explanation about the study.
Nothing severe
We were able to track the changes in the variant allele frequency of those genes and identify the potential gene mutations responsible for drug resistance.
Completed
2017 | Year | 05 | Month | 24 | Day |
2020 | Year | 07 | Month | 09 | Day |
2017 | Year | 06 | Month | 12 | Day |
2021 | Year | 05 | Month | 31 | Day |
2022 | Year | 05 | Month | 31 | Day |
Mutational analyses using the plasma DNA at baseline, 4 weeks and progressive disease will be performed and association with clinical information will be investigated.
2019 | Year | 01 | Month | 22 | Day |
2023 | Year | 07 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000040587
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