Unique ID issued by UMIN | UMIN000037080 |
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Receipt number | R000042247 |
Scientific Title | The role of autophagy in hepatocellular carcinoma induced by chronic liver diseases |
Date of disclosure of the study information | 2023/12/31 |
Last modified on | 2019/06/16 09:56:39 |
The mechanism of onset and development in liver cancer induced by nonalcoholic steatohepatitis (NASH) using human clinical materials
-From the view point of autophagy regulator p62 and antioxidative stress factor Nrf2-
The mechanism of liver cancer induced by NASH
The role of autophagy in hepatocellular carcinoma induced by chronic liver diseases
The relationship between hepatocellular carcinoma and autophagy
Japan |
Hepatocellular carcinoma induced by NASH
Hepato-biliary-pancreatic medicine |
Malignancy
NO
To clarify the role of p62 and Nrf2, regulators of autophagy, in the pathogenesis of hepatocellular carcinoma induced by nonalcoholic steatohepatitis
Others
To demonstrate the relationship between the levels of p62 or Nrf2 and the grade of malignancy or prognosis in hepatocellular carcinoma induced by NASH
The expression levels of p62 and Nrf2
the grade of malignancy, over all survival
Observational
25 | years-old | <= |
Not applicable |
Male and Female
Hepatocellular carcinoma induced by NASH or chronic hepatitis C, or metastasis from colon cancer
Hepatocellular carcinoma induced by chronic hepatitis B
150
1st name | Kosuke |
Middle name | |
Last name | Okada |
University of Tsukuba Hospital
Gastroenterology/ Tsukuba Preventive Medicine Research Center
305-8575
1-1-1 Tennoudai, Tsukuba, Ibaraki, JAPAN
029-853-3525
okadakosuke-2000@umin.ac.jp
1st name | Kosuke |
Middle name | |
Last name | Okada |
University of Tsukuba Hospital
Gastroenterology/ Tsukuba Preventive Medicine Research Center
305-8575
1-1-1 Tennoudai, Tsukuba, Ibaraki, JAPAN
029-853-3525
okadakosuke-2000@umin.ac.jp
University of Tsukuba Hospital
Japan Society for the Promotion of Science
Japanese Governmental office
University of Tsukuba Hospital
1-1-1 Tennoudai, Tsukuba, Ibaraki, JAPAN
029-853-3525
t-credo.adm@un.tsukuba.ac.jp
NO
2023 | Year | 12 | Month | 31 | Day |
Unpublished
Preinitiation
2018 | Year | 08 | Month | 23 | Day |
2019 | Year | 04 | Month | 01 | Day |
2023 | Year | 12 | Month | 31 | Day |
This program is the resarch of immunohistochemistry of Keap1-Nrf2 pathway and p62 in hepatocellular carcinoma induced by NASH using human materials.
2019 | Year | 06 | Month | 16 | Day |
2019 | Year | 06 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000042247
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