Unique ID issued by UMIN | UMIN000048089 |
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Receipt number | R000054809 |
Scientific Title | Establishment of a national registry for Behcet's disease |
Date of disclosure of the study information | 2022/06/17 |
Last modified on | 2022/06/17 14:29:32 |
Subgroup classification of Behcet's Disease Based on clinical findings and genome-wide subtyping based on clinical findings and establishment of a national registry
Establishment of a national registry for Behcet's disease
Establishment of a national registry for Behcet's disease
Establishment of a national registry for Behcet's disease
Japan |
Behcet disease
Clinical immunology |
Others
YES
In this study, we will first attempt to classify BD patients attending participating facilities and suspected cases that may develop BD in the future into subgroups based on relatively simple clinical information including clinical symptoms, age of onset, gender, and HLA. In addition, we will analyze the same cases over time to determine if there is any transfer between groups. In addition, a prospective study of new cases will be conducted. Next, we will analyze the relationship between each subgroup and known BD susceptibility genes, and perform GWAS restricted to each subgroup to elucidate the genetic predisposition that contributes to the pathogenesis of each subgroup and promote personalized medicine for each subtype. We will also compare cytokine profiles of serum and spinal fluid, and microbiomes of saliva and feces to investigate biological differences between subgroups, and in particular, to prove that intestinal BD is an independent pathology and prognosis. We will also accumulate basic data necessary for the establishment of a nationwide patient registry.
Others
None
None
Observational
Not applicable |
Not applicable |
Male and Female
Behcet's disease and suspected Behcet's disease cases
None
400
1st name | Yohei |
Middle name | |
Last name | Kirino |
Yokohama City University Graduate School of Medicine
Department of Stem Cell and Immune Regulation
2360004
3-9 Fukuura, Kanazawa-Ku, Yokohama, Japan
045-787-2800
kirino@yokohama-cu.ac.jp
1st name | Yohei |
Middle name | |
Last name | Kirino |
Yokohama City University Graduate School of Medicine
Department of Stem Cell and Immune Regulation
2360004
3-9 Fukuura, Kanazawa-Ku, Yokohama, Japan
045-787-2800
kirino@yokohama-cu.ac.jp
Yokohama City University Graduate School of Medicine
JSPS
Government offices of other countries
Yokohama City University Hospital
3-9 Fukuura, Kanazawa-Ku, Yokohama, Japan
045-787-2800
rinri@yokohama-cu.ac.jp
NO
2022 | Year | 06 | Month | 17 | Day |
Partially published
Enrolling by invitation
2017 | Year | 12 | Month | 11 | Day |
2020 | Year | 08 | Month | 28 | Day |
2017 | Year | 12 | Month | 11 | Day |
2022 | Year | 12 | Month | 10 | Day |
Basic information such as age, sex, age of onset, duration of disease, medical history and complications, family history, and preference history will be obtained from medical records of BD patients attending participating facilities, as well as suspected cases that may develop BD in the future. Statistical analysis of these associations will be performed to attempt to classify patients into subgroups. In addition, a longitudinal analysis will be conducted from the time of onset of symptoms to determine if there is any transition between groups due to the course of the disease or treatment. In addition, we will analyze the treatment content and response to the treatment.
In addition, we will analyze the association between each subgroup and disease susceptibility genes in cases in which SNPs in disease susceptibility genes have been identified. For cases that have not yet been analyzed, DNA will be extracted from blood samples collected from patients, and analysis including genome-wide association analysis will be conducted jointly by the Department of Ophthalmology and the Department of Ophthalmology of this hospital. Clinical specimens such as blood, spinal fluid, saliva, and stool will also be stored and analyzed (cytokine profile, microbiome, etc.) for comparison between subgroups. For the analysis of cytokine profiles, etc., healthy sera stored in the biobank room will be used for healthy subjects.
2022 | Year | 06 | Month | 17 | Day |
2022 | Year | 06 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000054809
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