Unique ID issued by UMIN | UMIN000049358 |
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Receipt number | R000056210 |
Scientific Title | Analysis of S100 protein in the duodenal juice collected by oral endoscopy to detect early stage pancreatic cancers: Accompanying research for sample preservation methods |
Date of disclosure of the study information | 2022/11/01 |
Last modified on | 2023/04/29 11:18:30 |
Analysis of S100 protein in the duodenal juice collected by oral endoscopy to detect early stage pancreatic cancers: Accompanying research for sample preservation methods
Analysis of S100 protein in the duodenal juice collected by oral endoscopy to detect early stage pancreatic cancers: Accompanying research for sample preservation methods
Analysis of S100 protein in the duodenal juice collected by oral endoscopy to detect early stage pancreatic cancers: Accompanying research for sample preservation methods
Analysis of S100 protein in the duodenal juice collected by oral endoscopy to detect early stage pancreatic cancers: Accompanying research for sample preservation methods
Japan |
Pancreatic cancer
Hepato-biliary-pancreatic medicine | Hepato-biliary-pancreatic surgery |
Malignancy
YES
The aim of this study is to assess the utility of S100 protein levels in the duodenal juice collected by oral endoscopy without pancreatic duct cannulation to detect pancreatic cancers.
Safety,Efficacy
The S100 protein concentration in the duodenal juice to detect patients with pancreatic cancers
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Device,equipment | Maneuver |
At the beginning of the endoscopy, the duodenum is entered within a few minutes and we collect the duodenal juice. The duodenal juice is collected within 3 minutes. Aspirate 45ul of the duodenal fluid injected into the empty tube with a pipette, add it to the diluent in which the protease inhibitor (Roche) was dissolved beforehand, and dilute it 101-fold. Dispense this into 3 bottles. Dissolve 1 tablet of protease inhibitor (Roche) in the remaining duodenal fluid. Dispense this into three tubes. Store one tube of each aliquot at -80 degree in a quick-freeze freezer. The remaining tubes are stored in a refrigerator at 4 degree. After 24 and 48 hours, remove one tube from each tube and store at -80 degree in a quick-freeze freezer.
50 | years-old | <= |
Not applicable |
Male and Female
Pancreatic cancer patients
1) Aged 50 or more
2) Patients who undergo preoperative screening upper gastrointestinal endoscopy or endoscopic ultrasonography (EUS) for the assessment of pancreatic cancer
3) Written informed consent
4) Patients without definite malignant diseases in upper gastrointestinal lesion except pancreatic cancer
5) Patients who have undergone no surgery in gastrointestinal lesion
6) Patients without malignant disease in bile duct
The patients who undergo physical examination
1) Aged 50 or more.
2) Patients proven to have normal pancreas by EUS
3) Patients who undergo screening upper gastrointestinal endoscopy for their pancreatic diseases
4) Written informed consent
5) Patients without definite malignant diseases in upper gastrointestinal lesion except pancreatic cancer
6) Patients who have undergone no surgery in gastrointestinal lesion, such as gastrectomy, pancreatoduodenectomy and so on.
7) Patients without malignant disease in bile duct
1) They have no drug hypersensitivity.
2) The doctor-in-charge figures them to be suitable for this study.
25
1st name | Masafumi |
Middle name | |
Last name | Nakamura |
Graduate School of Medical Sciences, Kyushu University
Department of Surgery and Oncology
812-8582
3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582 , Japan
092-631-2920
nakamura.masafumi.861@m.kyushu-u.ac.jp
1st name | Noboru |
Middle name | |
Last name | Ideno |
Graduate School of Medical Sciences, Kyushu University
Department of Surgery and Oncology
812-8582
3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582 , Japan
092-631-2920
ideno.noboru.033@m.kyushu-u.ac.jp
Graduate School of Medical Sciences, Kyushu University
Japan Agency for Medical Research and Development
Japanese Governmental office
Kyushu University
3-1-1-WW610, Maidashi, Higashi-Ku, Fukuoka, 812-8582 , Japan
092-642-5082
byskenkyu@jimu.kyushu-u.ac.jp
NO
2022 | Year | 11 | Month | 01 | Day |
Unpublished
20
No longer recruiting
2022 | Year | 10 | Month | 25 | Day |
2022 | Year | 10 | Month | 25 | Day |
2022 | Year | 10 | Month | 25 | Day |
2023 | Year | 03 | Month | 31 | Day |
2022 | Year | 10 | Month | 28 | Day |
2023 | Year | 04 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000056210
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