Unique ID issued by UMIN | UMIN000051712 |
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Receipt number | R000058977 |
Scientific Title | Comparison between stereotactic body radiotherapy and transcatheter arterial chemoembolization for hepatocellular carcinoma: Meta-analysis and systematic review. |
Date of disclosure of the study information | 2023/07/26 |
Last modified on | 2023/08/25 21:32:27 |
Comparison between stereotactic body radiotherapy and transcatheter arterial chemoembolization for hepatocellular carcinoma: Meta-analysis and systematic review.
Comparison between stereotactic body radiotherapy and transcatheter arterial chemoembolization for hepatocellular carcinoma: Meta-analysis and systematic review.
Comparison between stereotactic body radiotherapy and transcatheter arterial chemoembolization for hepatocellular carcinoma: Meta-analysis and systematic review.
Comparison between stereotactic body radiotherapy and transcatheter arterial chemoembolization for hepatocellular carcinoma: Meta-analysis and systematic review.
Japan |
Hepatocellular carcinoma
Hepato-biliary-pancreatic medicine | Radiology |
Malignancy
NO
In the Barcelona Clinic Liver Cancer staging and treatment strategy (BCLC) guideline, surgery, radiofrequency ablation (RFA), and trans-arterial chemoembolization (TACE) are considered as standard treatment for hepatocellular carcinoma (HCC). Although stereotactic body radiotherapy (SBRT) has been recognized as novel local therapy for HCC, SBRT is still not mentioned in BCLC guideline due to lack of randomized control trials. Recently, the randomized controlled trial which compared SBRT and TACE for HCC has published. However, the number of cases enrolled was too small to demonstrate the therapeutic efficacy of SBRT. In recent years, there are several retrospective studies which compared SBRT and TACE using propensity score matching (PSM). Aim of current meta-analysis is to summarize data from quality studies compared SBRT and TACE.
Efficacy
Hazard ratio of overall survival and local control
Others,meta-analysis etc
Not applicable |
Not applicable |
Male and Female
We will include observational studies using propensity score analysis and randomized controlled studies that compared SBRT and TACE for HCC. Articles were published as full reports, brief reports, or conference abstracts, regardless of their primary end point. Non-English reports were excluded.
N/A
1st name | Satoshi |
Middle name | |
Last name | Komiyama |
Yokohama City University Medical Center
Chemotherapy division/Gastroenterological Center
2320024
4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa
0452615656
skomiyam@yokohama-cu.ac.jp
1st name | Satoshi |
Middle name | |
Last name | Komiyama |
Yokohama City University Medical Center
Chemotherapy division/Gastroenterological Center
2320024
4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa
0452615656
skomiyam@yokohama-cu.ac.jp
Yokohama City University Medical Center
NA
Other
NA
NA
NA
NA
NO
2023 | Year | 07 | Month | 26 | Day |
Unpublished
No longer recruiting
2023 | Year | 07 | Month | 26 | Day |
2023 | Year | 07 | Month | 26 | Day |
2023 | Year | 07 | Month | 26 | Day |
2023 | Year | 07 | Month | 26 | Day |
Study Search
We will systematically search PubMed, the Cochrane database, EMBASE, and Web of Science as of August 1, 2023.
Reference lists in the included articles and review articles will be also hand searched.
Data synthesis
HR from propensity score matched studies will be pooled. Prior to generic inverse variance meta-analysis using RevMan 5.0 (Cochrane Collaboration, London, UK), HR will be log converted.
Subgroup analyses which focus on liver function will be performed.
Statistical significance will be judged by P 0.05.
2023 | Year | 07 | Month | 26 | Day |
2023 | Year | 08 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000058977
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