Unique ID issued by UMIN | UMIN000053039 |
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Receipt number | R000060446 |
Scientific Title | Validation of the prevalence of RNF213 variants in patients with non-obstructive coronary artery disease (INOCA) for precision medicine and creation of a polygenic risk score model for the development of INOCA. |
Date of disclosure of the study information | 2023/12/11 |
Last modified on | 2023/12/08 22:35:46 |
Validation of the prevalence of RNF213 variants in patients with non-obstructive coronary artery disease (INOCA) for precision medicine and creation of a polygenic risk score model for the development of INOCA.
Validation of the prevalence of RNF213 variants in patients with non-obstructive coronary artery disease (INOCA) for precision medicine and creation of a polygenic risk score model for the development of INOCA.
Validation of the prevalence of RNF213 variants in patients with non-obstructive coronary artery disease (INOCA) for precision medicine and creation of a polygenic risk score model for the development of INOCA.
Validation of the prevalence of RNF213 variants in patients with non-obstructive coronary artery disease (INOCA) for precision medicine and creation of a polygenic risk score model for the development of INOCA.
Japan |
coronary artery disease (including coronary spastic angina, and coronary microvascular dysfunction)
Cardiology |
Others
YES
The RNF213 gene polymorphism, which has been reported to be associated with Moyamoya disease, is suggested to be linked to atherosclerotic cerebral infarction and coronary spastic angina. This study aims to investigate the prevalence of the RNF213 gene polymorphism in non-obstructive coronary artery disease and clarify the clinical characteristics and prognosis of individuals with and without the polymorphism. The further objective is to create of a polygenic risk score model for the development of INOCA.
Others
Determination of polygenic risk in non-obstructive coronary artery disease
A polygenic risk score model for the development of INOCA
The prevalence of RNF213 variants, Prognosis, Therapeutic resistance, Rehospitalization, Vasoreactivity
Observational
Not applicable |
Not applicable |
Male and Female
Non-obstructive coronary artery disease
Patients deemed inappropriate for participation in this study by the researcher
Patients who declined the use of information for research
330
1st name | Noguchi |
Middle name | |
Last name | Teruo |
National Cerebral and Cardiovascular Center
Cardiovascular department
564-8565
6-1 Kishibe-Shimmachi, Suita, Osaka
0661701070
tnoguchi@ncvc.go.jp
1st name | Noguchi |
Middle name | |
Last name | Teruo |
National Cerebral and Cardiovascular Center
Cardiovascular department
564-8565
6-1 Kishibe-Shimmachi, Suita, Osaka
0661701070
tnoguchi@ncvc.go.jp
National Cerebral and Cardiovascular Center
Japan Agency for Medical Research and Development
Japanese Governmental office
Clinical Research Board
6-1 Kishibe-Shimmachi, Suita, Osaka
0661701070
crb-office@ncvc.go.jp
NO
2023 | Year | 12 | Month | 11 | Day |
Unpublished
Open public recruiting
2023 | Year | 06 | Month | 07 | Day |
2023 | Year | 08 | Month | 01 | Day |
2023 | Year | 08 | Month | 10 | Day |
2026 | Year | 03 | Month | 31 | Day |
This study aims to investigate the clinical characteristics based on RNF213 gene polymorphism in patients with non-obstructive coronary artery disease (INOCA), and to create a polygenic risk score model associated with the development of INOCA.
2023 | Year | 12 | Month | 08 | Day |
2023 | Year | 12 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000060446
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